PMID- 34657257
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 12
DP  - 2022 Mar
TI  - Fully-automated SPE coupled to UHPLC-MS/MS method for multiresidue analysis of 26 
      trace antibiotics in environmental waters: SPE optimization and method 
      validation.
PG  - 16973-16987
LID - 10.1007/s11356-021-15947-3 [doi]
AB  - Achieving simultaneous determination of antibiotic multiresidues in environmental 
      waters by solid phase extraction (SPE) coupled with ultra-high-performance liquid 
      chromatography tandem mass spectrometry (UHPLC-MS/MS) with detection limits </= ng 
      L(-1) is still a huge challenge. Moreover, the offline SPE procedure was 
      performed manually, costly, and time-consuming, while the online SPE required 
      precision pretreatment instruments that require highly-skilled personnel. In this 
      paper, a fully automated SPE coupled with UHPLC-MS/MS method was developed for 
      analysis of antibiotics (sulfonamides, quinolones, and macrolides) in water 
      matrices. Sample preparation optimization included SPE materials and 
      configuration (HLB disks), sample volume (500-1000 mL), and pH (pH = 3) with a 
      flow rate at 2~5 mL min(-1), and an elution procedure with 2 x 6 mL methanol, and 
      2 x 6 mL acetone. Meanwhile, the parameters for UHPLC-MS/S detection of analytes 
      were optimized, including LC retention time, and MS parameters. The instrumental 
      limits of detection (LOD) and quantification (LOQ) of analytes ranged from 
      0.01-0.72 mug L(-1) and 0.05-2.39 mug L(-1), respectively, with satisfactory linear 
      calibration (R(2) > 0.995) and precision (< 9.9%). Recoveries in spike samples 
      ranged between 77.5-104.9% in pure water, 59.4-97.8% in surface water (SW), and 
      58.2-108.6% in wastewater effluent (WWE) with relative standard deviations </= 
      12.8%. The matrix effects observed for most analytes were suppression (0-28.1%) 
      except for five analytes having presented enhancement (0-14.6 %) in SW or WWE. 
      This method can basically meet the needs of trace antibiotic residues detection 
      in waters, with examples of concentrations of detected antibiotics being lower 
      than LOQ (LLQ) -94.47 ng L(-1) in WWEs and LLQ-15.47 ng L(-1) in SW in the lower 
      reaches of the Yangtze River Basin.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zheng, Ming
AU  - Zheng M
AUID- ORCID: 0000-0003-3737-0577
AD  - Key Laboratory of Organic Compound Pollution Control Engineering, School of 
      Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, 
      China. zmshu@shu.edu.cn.
FAU - Tang, Suwen
AU  - Tang S
AD  - Key Laboratory of Organic Compound Pollution Control Engineering, School of 
      Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, 
      China.
FAU - Bao, Yangyang
AU  - Bao Y
AD  - Pudong New Area Environmental Monitoring Station, No.51 Lingshan Road. Pudong New 
      Area, Shanghai, China.
FAU - Daniels, Kevin D
AU  - Daniels KD
AD  - Hazen and Sawyer, 1400 E. Southern Ave, Tempe, AZ, 85282, USA.
FAU - How, Zuo Tong
AU  - How ZT
AD  - Department of Civil & Environmental Engineering, University of Alberta, Edmonton, 
      Alberta, T6G 1H9, Canada.
FAU - El-Din, Mohamed Gamal
AU  - El-Din MG
AD  - Department of Civil & Environmental Engineering, University of Alberta, Edmonton, 
      Alberta, T6G 1H9, Canada.
FAU - Wang, Jie
AU  - Wang J
AD  - Fishery Machinery and Instrument Research Institute of Chinese Academy of Fishery 
      Sciences, Shanghai, China.
FAU - Tang, Liang
AU  - Tang L
AD  - Key Laboratory of Organic Compound Pollution Control Engineering, School of 
      Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, 
      China. tang1liang@shu.edu.cn.
LA  - eng
GR  - 2020YFC1808200/National Key Research and Development Project/
GR  - 2020M671067/China Postdoctoral Science Foundation/
GR  - 18YF1407500/Shanghai Sailing Program/
PT  - Journal Article
DEP - 20211016
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Water Pollutants, Chemical)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Anti-Bacterial Agents
MH  - Chromatography, High Pressure Liquid
MH  - Solid Phase Extraction
MH  - *Tandem Mass Spectrometry
MH  - Water
MH  - *Water Pollutants, Chemical
OTO - NOTNLM
OT  - Environmental water samples
OT  - SPE optimization
OT  - Sulfonamide, quinolone, and macrolide antibiotics
OT  - UHPLC-MS/MS
OT  - Validation
EDAT- 2021/10/18 06:00
MHDA- 2022/03/03 06:00
CRDT- 2021/10/17 21:00
PHST- 2021/04/22 00:00 [received]
PHST- 2021/08/09 00:00 [accepted]
PHST- 2021/10/18 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/10/17 21:00 [entrez]
AID - 10.1007/s11356-021-15947-3 [pii]
AID - 10.1007/s11356-021-15947-3 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Mar;29(12):16973-16987. doi: 
      10.1007/s11356-021-15947-3. Epub 2021 Oct 16.