PMID- 34657771
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1873-2607 (Electronic)
IS  - 0749-3797 (Linking)
VI  - 62
IP  - 2
DP  - 2022 Feb
TI  - Characteristics of Scientific Evidence Informing Changed U.S. Preventive Services 
      Task Force Insufficient Evidence Statements.
PG  - e77-e86
LID - S0749-3797(21)00457-8 [pii]
LID - 10.1016/j.amepre.2021.07.014 [doi]
AB  - INTRODUCTION: The U.S. Preventive Services Task Force (USPSTF) issues 
      "Insufficient Evidence" (I) statements when scientific evidence is inadequate for 
      making recommendations about clinical preventive services. Insufficient Evidence 
      statements may be changed to definitive recommendations if new research closes 
      evidence gaps. This study examines the characteristics of evidence that informed 
      changes from I statements to definitive recommendations, including NIH's role as 
      a funder. METHODS: A total of 11 USPSTF Insufficient Evidence statements that 
      were changed between 2010 and 2019 were assessed. Study designs, bibliometric 
      influence, and funding sources for scientific articles cited in USPSTF evidence 
      reviews were characterized for each I statement. Data were analyzed in 2019-2020. 
      RESULTS: Most I statements (82%) changed to a B grade; an average of 8.4 years 
      elapsed between issuing the I statement and releasing the definitive 
      recommendation. An average of 63 (range=19-253) articles were included in each 
      USPSTF evidence review. NIH support was cited in 28.8% of articles, on average. 
      The proportion of NIH-funded articles reporting RCT designs was similar to that 
      of non-NIH-funded articles (64.5% vs 59.5%). A higher proportion of NIH-funded 
      articles were rated good quality for study design (39.0%) than the proportion of 
      non-NIH-funded articles (24.4%). Bibliometric influence measured by relative 
      citation ratios was higher for NIH-funded (mean=14.78) than for non-NIH-funded 
      (mean=5.07) articles. CONCLUSIONS: Study designs and funding supports varied 
      widely across topics, but overall, NIH was the largest single funder of evidence 
      informing 11 changed USPSTF I statements. Enhanced efforts by NIH and other 
      stakeholders to address I statement evidence gaps are needed.
CI  - Published by Elsevier Inc.
FAU - Klabunde, Carrie N
AU  - Klabunde CN
AD  - Office of Disease Prevention, Division of Program Coordination Planning and 
      Strategic Initiatives, Office of the Director, NIH, Bethesda, Maryland. 
      Electronic address: KlabundC@mail.nih.gov.
FAU - Ellis, Erin M
AU  - Ellis EM
AD  - Office of Disease Prevention, Division of Program Coordination Planning and 
      Strategic Initiatives, Office of the Director, NIH, Bethesda, Maryland.
FAU - Villani, Jennifer
AU  - Villani J
AD  - Office of Disease Prevention, Division of Program Coordination Planning and 
      Strategic Initiatives, Office of the Director, NIH, Bethesda, Maryland.
FAU - Neilson, Elizabeth
AU  - Neilson E
AD  - Office of Disease Prevention, Division of Program Coordination Planning and 
      Strategic Initiatives, Office of the Director, NIH, Bethesda, Maryland.
FAU - Schwartz, Kat
AU  - Schwartz K
AD  - Office of Disease Prevention, Division of Program Coordination Planning and 
      Strategic Initiatives, Office of the Director, NIH, Bethesda, Maryland.
FAU - Vogt, Elizabeth A
AU  - Vogt EA
AD  - Office of Disease Prevention, Division of Program Coordination Planning and 
      Strategic Initiatives, Office of the Director, NIH, Bethesda, Maryland.
FAU - Ngo-Metzger, Quyen
AU  - Ngo-Metzger Q
AD  - Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School 
      of Medicine, Pasadena, California.
LA  - eng
PT  - Journal Article
DEP - 20211015
PL  - Netherlands
TA  - Am J Prev Med
JT  - American journal of preventive medicine
JID - 8704773
SB  - IM
MH  - *Advisory Committees
MH  - Humans
MH  - *Preventive Health Services
EDAT- 2021/10/19 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/10/18 05:33
PHST- 2021/03/25 00:00 [received]
PHST- 2021/07/22 00:00 [revised]
PHST- 2021/07/28 00:00 [accepted]
PHST- 2021/10/19 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/10/18 05:33 [entrez]
AID - S0749-3797(21)00457-8 [pii]
AID - 10.1016/j.amepre.2021.07.014 [doi]
PST - ppublish
SO  - Am J Prev Med. 2022 Feb;62(2):e77-e86. doi: 10.1016/j.amepre.2021.07.014. Epub 
      2021 Oct 15.