PMID- 34657898
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220531
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 69
IP  - 3
DP  - 2022 Mar 28
TI  - Clinical significance of high mobility group box 1/toll-like receptor 4 in obese 
      diabetic patients.
PG  - 235-242
LID - 10.1507/endocrj.EJ21-0381 [doi]
AB  - High mobility group box 1 (HMGB1) is an alarmin that may link to obesity and type 
      2 diabetes mellitus (T2DM). The present study analyzed the correlation between 
      HMGB1/ Toll-like receptor 4 (TLR4) and certain biochemical parameters in obese 
      (OB) diabetic patients. 40 normal glucose tolerant subjects (NGT) and 40 patients 
      with newly diagnosed T2DM were enrolled. All patients were further divided into 
      non-obese NGT (NGT-NOB), obese NGT (NGT-OB), non-obese T2DM (T2DM-NOB) and obese 
      T2DM (T2DM-OB) groups according to body mass index (BMI).The levels of HMGB1 in 
      serum were quantified using ELISA, whereas the mRNA expression levels of TLR4 in 
      peripheral blood mononuclear cells were assessed using reverse 
      transcription-quantitative PCR. The results suggested that the levels of HMGB1 
      and TLR4 were higher in NGT-OB and T2DM-NOB groups compared with those in NGT-NOB 
      group. Similarly, the levels of these two markers were higher in T2DM-OB group 
      compared with those in NGT-OB group. Correlation analysis indicated that the 
      levels of HMGB1 and TLR4 were positively correlated with triglyceride (TG), 
      fasting plasma glucose (FPG) levels and BMI, whereas a negative correlation 
      between HMGB1 and high density lipoprotein (HDL) was noted. Linear regression 
      analysis suggested that HMGB1 was associated with FPG and TG levels, whereas TLR4 
      was strongly associated with TG levels and BMI. The results demonstrated that the 
      expression levels of HMGB1 and TLR4 in patients with T2DM or obesity were 
      increased, which were associated with glycolipid metabolism disorders. Therefore, 
      the HMGB1/TLR4 may serve a role in inflammatory process associated with obesity 
      and T2DM.
FAU - Liu, Shuai
AU  - Liu S
AD  - Department of Blood Transfusion, the Third Affiliated Hospital of Xinxiang 
      Medical University, Henan Xinxiang, 453003, China.
FAU - Wang, Xianchun
AU  - Wang X
AD  - Clinical laboratory, the Third Affiliated Hospital of Xinxiang Medical 
      University, Henan Xinxiang, 453003, China.
FAU - Kai, Yue
AU  - Kai Y
AD  - Department of Immunology, School of Basic Medical Sciences, Xinxiang Medical 
      University, Henan Xinxiang, 453003, China.
AD  - Xinxiang Key Laboratory of Tumor Vaccine and Immunotherapy, Xinxiang Medical 
      University, Henan Xinxiang, 453000, China.
FAU - Tian, Chenrui
AU  - Tian C
AD  - Department of Immunology, School of Basic Medical Sciences, Xinxiang Medical 
      University, Henan Xinxiang, 453003, China.
AD  - Xinxiang Key Laboratory of Tumor Vaccine and Immunotherapy, Xinxiang Medical 
      University, Henan Xinxiang, 453000, China.
FAU - Guo, Sheng
AU  - Guo S
AD  - Department of Immunology, School of Basic Medical Sciences, Xinxiang Medical 
      University, Henan Xinxiang, 453003, China.
AD  - Xinxiang Key Laboratory of Tumor Vaccine and Immunotherapy, Xinxiang Medical 
      University, Henan Xinxiang, 453000, China.
FAU - He, Ling
AU  - He L
AD  - Department of Ophthalmology, the 371 Affiliated Hospital of Xinxiang Medical 
      University, Henan Xinxiang, 453003, China.
FAU - Zhai, Desheng
AU  - Zhai D
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Xinxiang 
      Medical University, Henan Xinxiang, 453003, China.
FAU - Song, Xiangfeng
AU  - Song X
AD  - Department of Immunology, School of Basic Medical Sciences, Xinxiang Medical 
      University, Henan Xinxiang, 453003, China.
AD  - Xinxiang Key Laboratory of Tumor Vaccine and Immunotherapy, Xinxiang Medical 
      University, Henan Xinxiang, 453000, China.
LA  - eng
PT  - Journal Article
DEP - 20211015
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (HMGB1 Protein)
RN  - 0 (HMGB1 protein, human)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/complications
MH  - HMGB1 Protein
MH  - Humans
MH  - Leukocytes, Mononuclear
MH  - Obesity/complications
MH  - *Toll-Like Receptor 4/genetics
OTO - NOTNLM
OT  - High mobility group box 1
OT  - Obesity
OT  - Regression analysis
OT  - Toll-like receptor 4
OT  - Type 2 diabetes mellitus
EDAT- 2021/10/19 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/10/18 05:36
PHST- 2021/10/19 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/10/18 05:36 [entrez]
AID - 10.1507/endocrj.EJ21-0381 [doi]
PST - ppublish
SO  - Endocr J. 2022 Mar 28;69(3):235-242. doi: 10.1507/endocrj.EJ21-0381. Epub 2021 
      Oct 15.