PMID- 34660245
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 25
IP  - 2
DP  - 2021 Mar-Apr
TI  - Adipose Tissue Levels of DDT as Risk Factor for Obesity and Type 2 Diabetes 
      Mellitus.
PG  - 160-165
LID - 10.4103/ijem.ijem_198_21 [doi]
AB  - BACKGROUND: Exposure to dichlorodiphenyltrichloroethane (DDT), a potent 
      lipophilic organochlorine pesticide, has long been linked as a risk factor for 
      type 2 diabetes mellitus (T2DM). However, its presence in the adipose tissues of 
      the T2DM subjects has not been explored in the Indian population, where this 
      long-banned pesticide is still in use. The present study was conducted to 
      evaluate the possible association of DDT and its metabolites in obese and 
      non-obese T2DM subjects. METHODS: Subjects with normal glucose tolerance (n = 50) 
      and T2DM (n = 50) were divided into equal numbers in obese and non-obese groups. 
      Their plasma glucose levels, HbA(1)c, and lipid profile were measured. The 
      adipose tissues were collected intraoperatively, and DDT and its metabolites were 
      measured using a gas chromatograph equipped with an electron capture detector. 
      RESULTS: Obese subjects, irrespective of their glycemic status, and T2DM subjects 
      had higher concentrations of DDT. p, p' DDT was found to increase the odds for 
      diabetes, and o, p' DDT for central obesity. p, p' DDD was also strongly 
      correlated with central obesity, glycemic parameters, and triglycerides. 
      CONCLUSION: The excess deposition of p, p' DDD, o, p' DDT, and p, p' DDT in obese 
      subjects may proceed to T2DM by disrupting triglycerides and glycemic parameters.
CI  - Copyright: (c) 2021 Indian Journal of Endocrinology and Metabolism.
FAU - Tawar, Neha
AU  - Tawar N
AD  - Department of Biochemistry, University College of Medical Sciences (UCMS) and GTB 
      Hospital (University of Delhi), Dilshad Garden, Delhi, India.
FAU - Banerjee, Basu Dev
AU  - Banerjee BD
AD  - Department of Biochemistry, University College of Medical Sciences (UCMS) and GTB 
      Hospital (University of Delhi), Dilshad Garden, Delhi, India.
FAU - Mishra, Brijesh Kumar
AU  - Mishra BK
AD  - Department of Diabetes Endocrinology and Metabolism, University College of 
      Medical Sciences (UCMS) and GTB Hospital (University of Delhi), Dilshad Garden, 
      Delhi, India.
FAU - Sharma, Tusha
AU  - Sharma T
AD  - Department of Biochemistry, University College of Medical Sciences (UCMS) and GTB 
      Hospital (University of Delhi), Dilshad Garden, Delhi, India.
FAU - Tyagi, Shipra
AU  - Tyagi S
AD  - Department of Environmental Studies, University of Delhi, Delhi, India.
FAU - Madhu, Sri Venkata
AU  - Madhu SV
AD  - Department of Diabetes Endocrinology and Metabolism, University College of 
      Medical Sciences (UCMS) and GTB Hospital (University of Delhi), Dilshad Garden, 
      Delhi, India.
FAU - Agarwal, Vivek
AU  - Agarwal V
AD  - Department of Surgery, University College of Medical Sciences (UCMS) and GTB 
      Hospital (University of Delhi), Dilshad Garden, Delhi, India.
FAU - Gupta, Sanjay
AU  - Gupta S
AD  - Department of Surgery, University College of Medical Sciences (UCMS) and GTB 
      Hospital (University of Delhi), Dilshad Garden, Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20210908
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC8477732
OTO - NOTNLM
OT  - Adipose tissue
OT  - DDD
OT  - DDT
OT  - T2DM
OT  - central obesity
COIS- There are no conflicts of interest.
EDAT- 2021/10/19 06:00
MHDA- 2021/10/19 06:01
PMCR- 2021/03/01
CRDT- 2021/10/18 09:06
PHST- 2021/05/09 00:00 [received]
PHST- 2021/07/14 00:00 [revised]
PHST- 2021/07/18 00:00 [accepted]
PHST- 2021/10/18 09:06 [entrez]
PHST- 2021/10/19 06:00 [pubmed]
PHST- 2021/10/19 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - IJEM-25-160 [pii]
AID - 10.4103/ijem.ijem_198_21 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2021 Mar-Apr;25(2):160-165. doi: 
      10.4103/ijem.ijem_198_21. Epub 2021 Sep 8.