PMID- 34660711
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230917
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Characterization of Flow Dynamics in the Pulmonary Bifurcation of Patients With 
      Repaired Tetralogy of Fallot: A Computational Approach.
PG  - 703717
LID - 10.3389/fcvm.2021.703717 [doi]
LID - 703717
AB  - The hemodynamic environment of the pulmonary bifurcation is of great importance 
      for adult patients with repaired tetralogy of Fallot (rTOF) due to possible 
      complications in the pulmonary valve and narrowing of the left pulmonary artery 
      (LPA). The aim of this study was to computationally investigate the effect of 
      geometrical variability and flow split on blood flow characteristics in the 
      pulmonary trunk of patient-specific models. Data from a cohort of seven patients 
      was used retrospectively and the pulmonary hemodynamics was investigated using 
      averaged and MRI-derived patient-specific boundary conditions on the 
      individualized models, as well as a statistical mean geometry. Geometrical 
      analysis showed that curvature and tortuosity are higher in the LPA branch, 
      compared to the right pulmonary artery (RPA), resulting in complex flow patterns 
      in the LPA. The computational analysis also demonstrated high time-averaged wall 
      shear stress (TAWSS) at the outer wall of the LPA and the wall of the RPA 
      proximal to the junction. Similar TAWSS patterns were observed for averaged 
      boundary conditions, except for a significantly modified flow split assigned at 
      the outlets. Overall, this study enhances our understanding about the flow 
      development in the pulmonary bifurcation of rTOF patients and associates some 
      morphological characteristics with hemodynamic parameters, highlighting the 
      importance of patient-specificity in the models. To confirm these findings, 
      further studies are required with a bigger cohort of patients.
CI  - Copyright (c) 2021 Boumpouli, Sauvage, Capelli, Schievano and Kazakidi.
FAU - Boumpouli, Maria
AU  - Boumpouli M
AD  - Department of Biomedical Engineering, University of Strathclyde, Glasgow, United 
      Kingdom.
FAU - Sauvage, Emilie L
AU  - Sauvage EL
AD  - Institute of Cardiovascular Science and Great Ormond Street Hospital for 
      Children, NHS Foundation Trust, University College London, London, United 
      Kingdom.
FAU - Capelli, Claudio
AU  - Capelli C
AD  - Institute of Cardiovascular Science and Great Ormond Street Hospital for 
      Children, NHS Foundation Trust, University College London, London, United 
      Kingdom.
FAU - Schievano, Silvia
AU  - Schievano S
AD  - Institute of Cardiovascular Science and Great Ormond Street Hospital for 
      Children, NHS Foundation Trust, University College London, London, United 
      Kingdom.
FAU - Kazakidi, Asimina
AU  - Kazakidi A
AD  - Department of Biomedical Engineering, University of Strathclyde, Glasgow, United 
      Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20210930
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8514754
OTO - NOTNLM
OT  - computational fluid dynamics
OT  - congenital heart disease
OT  - hemodynamics
OT  - pulmonary bifurcation
OT  - tetralogy of Fallot
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/19 06:00
MHDA- 2021/10/19 06:01
PMCR- 2021/01/01
CRDT- 2021/10/18 09:08
PHST- 2021/04/30 00:00 [received]
PHST- 2021/09/07 00:00 [accepted]
PHST- 2021/10/18 09:08 [entrez]
PHST- 2021/10/19 06:00 [pubmed]
PHST- 2021/10/19 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.703717 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Sep 30;8:703717. doi: 10.3389/fcvm.2021.703717. 
      eCollection 2021.