PMID- 34661053
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2514-2119 (Electronic)
IS  - 2514-2119 (Linking)
VI  - 5
IP  - 10
DP  - 2021 Oct
TI  - Severe mitral regurgitation from Libman-Sacks endocarditis treated with 
      MitraClip: a case report.
PG  - ytab361
LID - 10.1093/ehjcr/ytab361 [doi]
LID - ytab361
AB  - BACKGROUND: Systemic lupus erythematosus (SLE) valvulopathy can manifest as a 
      spectrum of pathologies and treatment of severe valvular dysfunction thus far has 
      been surgical. However, surgery in patients with SLE is frequently associated 
      with high morbidity and mortality due to the presence of significant 
      co-morbidities. CASE SUMMARY: We report the case of a 41-year-old woman with SLE 
      and anti-phospholipid syndrome with extensive co-morbidities including lupus 
      nephritis, pancytopaenia, cerebrovascular accident, and severe airway obstruction 
      from ipsilateral lung collapse and bronchiectasis. She had severe mitral 
      regurgitation (MR) from Libman-Sacks endocarditis and in recent months developed 
      heart failure with progressive exertional dyspnoea from New York Heart 
      Association (NYHA) functional Class from New York Heart Association (NYHA) 
      functional class II to III. In addition, there was progressive left ventricular 
      dilatation and reduction in left ventricular ejection fraction. In view of the 
      high surgical risk, she underwent transcatheter edge-to-edge repair (TEER) of the 
      mitral valve with the MitraClip system. At 1-month follow-up, she was back to 
      NYHA functional Class II with mild MR. DISCUSSION: Our case demonstrates that in 
      select patient with suitable anatomy, TEER is a potential treatment option for 
      severe MR from SLE valvulopathy.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Ningyan, Wong
AU  - Ningyan W
AD  - Department of Cardiology, National Heart Centre, 5 Hospital Drive, Singapore 
      169609, Singapore.
FAU - Jappar, Ignasius Aditya
AU  - Jappar IA
AUID- ORCID: 0000-0002-9030-0765
AD  - Department of Cardiology, National Heart Centre, 5 Hospital Drive, Singapore 
      169609, Singapore.
FAU - See Hooi, Ewe
AU  - See Hooi E
AD  - Department of Cardiology, National Heart Centre, 5 Hospital Drive, Singapore 
      169609, Singapore.
FAU - Khung Keong, Yeo
AU  - Khung Keong Y
AD  - Department of Cardiology, National Heart Centre, 5 Hospital Drive, Singapore 
      169609, Singapore.
LA  - eng
PT  - Case Reports
DEP - 20211011
PL  - England
TA  - Eur Heart J Case Rep
JT  - European heart journal. Case reports
JID - 101730741
PMC - PMC8517867
OTO - NOTNLM
OT  - Case report
OT  - Libman-Sacks endocarditis
OT  - MitraClip
OT  - Mitral regurgitation
OT  - Systemic lupus erythematosus
EDAT- 2021/10/19 06:00
MHDA- 2021/10/19 06:01
PMCR- 2021/10/11
CRDT- 2021/10/18 09:13
PHST- 2021/04/03 00:00 [received]
PHST- 2021/05/07 00:00 [revised]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2021/10/18 09:13 [entrez]
PHST- 2021/10/19 06:00 [pubmed]
PHST- 2021/10/19 06:01 [medline]
PHST- 2021/10/11 00:00 [pmc-release]
AID - ytab361 [pii]
AID - 10.1093/ehjcr/ytab361 [doi]
PST - epublish
SO  - Eur Heart J Case Rep. 2021 Oct 11;5(10):ytab361. doi: 10.1093/ehjcr/ytab361. 
      eCollection 2021 Oct.