PMID- 34662552
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 286
DP  - 2021 Dec 1
TI  - The impact of hypoxia on immune state in cancer.
PG  - 120057
LID - S0024-3205(21)01044-4 [pii]
LID - 10.1016/j.lfs.2021.120057 [doi]
AB  - Hypoxia is a known feature of solid tumors and a critical promoter of tumor 
      hallmarks. Hypoxia influences tumor immunity in a way favoring immune evasion and 
      resistance. Extreme hypoxia and aberrant hypoxia-inducible factor-1 (HIF-1) 
      activity in tumor microenvironment (TME) is a drawback for effective 
      immunotherapy. Infiltration and activity of CD8(+) T cells is reduced in such 
      condition, whereas regulatory T cells (Tregs) and myeloid-derived suppressor 
      cells (MDSCs) show high activities. Highly hypoxic TME also impairs maturation 
      and activity of dendritic cell (DCs) and natural killer (NK) cells. In addition, 
      the hypoxic TME positively is linked positively with metabolic changes in cells 
      of immune system. These alterations are indicative of a need for hypoxia 
      modulation as a complementary targeting strategy to go with immune checkpoint 
      inhibitor (ICI) therapy.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Mortezaee, Keywan
AU  - Mortezaee K
AD  - Department of Anatomy, School of Medicine, Kurdistan University of Medical 
      Sciences, Sanandaj, Iran. Electronic address: mortezaee.k@muk.ac.ir.
FAU - Majidpoor, Jamal
AU  - Majidpoor J
AD  - Department of Anatomy, School of Medicine, Infectious Disease Research Center, 
      Gonabad University of Medical Sciences, Gonabad, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211016
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Humans
MH  - Hypoxia/*metabolism/physiopathology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism/physiology
MH  - Killer Cells, Natural/immunology
MH  - Myeloid-Derived Suppressor Cells/immunology
MH  - Neoplasms/*immunology/*metabolism
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Tumor Microenvironment/immunology
OTO - NOTNLM
OT  - CD8(+) T cell
OT  - Dendritic cell (DC)
OT  - Hypoxia
OT  - Hypoxia inducible factor (HIF)
OT  - Immune checkpoint inhibitor (ICI)
OT  - Natural killer (NK)
OT  - Tumor microenvironment (TME)
EDAT- 2021/10/19 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/10/18 20:10
PHST- 2021/08/24 00:00 [received]
PHST- 2021/10/10 00:00 [revised]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/19 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/10/18 20:10 [entrez]
AID - S0024-3205(21)01044-4 [pii]
AID - 10.1016/j.lfs.2021.120057 [doi]
PST - ppublish
SO  - Life Sci. 2021 Dec 1;286:120057. doi: 10.1016/j.lfs.2021.120057. Epub 2021 Oct 
      16.