PMID- 34663557
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 71
IP  - 2
DP  - 2022 Apr
TI  - Is oral food challenge useful to avoid complete elimination in Japanese patients 
      diagnosed with or suspected of having IgE-dependent hen's egg allergy? A 
      systematic review.
PG  - 221-229
LID - S1323-8930(21)00125-8 [pii]
LID - 10.1016/j.alit.2021.09.005 [doi]
AB  - BACKGROUND: IgE-mediated egg allergy is a common food allergy worldwide. Patients 
      with egg allergy are known to easily achieve tolerance compared to other 
      allergens such as nuts. Oral food challenge (OFC) is often performed on patients 
      diagnosed with or suspected of having IgE-mediated food allergy, but whether 
      hen's egg OFC is useful in IgE-dependent egg allergy patients to avoid complete 
      elimination remains unknown. METHODS: We identified articles in which OFCs were 
      performed in Japanese patients diagnosed with or suspected of having IgE-mediated 
      egg allergy. We evaluated whether the OFCs were useful to avoid the complete 
      elimination of eggs by assessing the following: (1) the number of patients who 
      could avoid complete elimination; (2) the number of patients who experienced 
      serious adverse events (SAEs); or (3) adverse events (AEs); (4) improvement in 
      quality of life (QOL); and (5) immunological changes. RESULTS: Fifty-nine 
      articles were selected in the study; all the references were case series or case 
      studies in which OFC was compared to pre-challenge conditions. The overall 
      negative ratio against egg OFC was 62.7%, but an additional 71.9% of OFC-positive 
      patients could take eggs when expanded to partial elimination. Of the 4182 cases, 
      1146 showed AEs in the OFC, and two cases reached an SAE. Two reports showed an 
      improvement in QOL and immunological changes, although the evidence was weak. 
      CONCLUSIONS: OFCs against eggs may be useful to avoid complete elimination, but 
      medical professionals should proceed with the test safely and carefully.
CI  - Copyright (c) 2021 Japanese Society of Allergology. Production and hosting by 
      Elsevier B.V. All rights reserved.
FAU - Murai, Hiroki
AU  - Murai H
AD  - Department of Pediatrics, University of Fukui, Fukui, Japan.
FAU - Irahara, Makoto
AU  - Irahara M
AD  - Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
FAU - Sugimoto, Mayumi
AU  - Sugimoto M
AD  - Department of Pediatrics, Tokushima University Hospital, Tokushima, Japan.
FAU - Takaoka, Yuri
AU  - Takaoka Y
AD  - Department of Pediatrics, Osaka Habikino Medical Center, Osaka, Japan.
FAU - Takahashi, Kyohei
AU  - Takahashi K
AD  - Department of Pediatrics, National Hospital Organization Sagamihara National 
      Hospital, Kanagawa, Japan.
FAU - Wada, Takuya
AU  - Wada T
AD  - Department of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, 
      Japan.
FAU - Yamamoto-Hanada, Kiwako
AU  - Yamamoto-Hanada K
AD  - Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
FAU - Okafuji, Ikuo
AU  - Okafuji I
AD  - Department of Pediatrics, Kobe City Medical Center General Hospital, Hyogo, 
      Japan.
FAU - Yamada, Yoshiyuki
AU  - Yamada Y
AD  - Division of Allergy and Immunology, Gunma Children's Medical Center, Gunma, 
      Japan; Department of Pediatrics, Tokai University School of Medicine, Kanagawa, 
      Japan.
FAU - Futamura, Masaki
AU  - Futamura M
AD  - Department of Pediatrics, National Hospital Organization Nagoya Medical Center, 
      Aichi, Japan.
FAU - Ebisawa, Motohiro
AU  - Ebisawa M
AD  - Clinical Research Center for Allergology and Rheumatology, National Hospital 
      Organization Sagamihara National Hospital, Kanagawa, Japan. Electronic address: 
      mebisawa@foodallergy.jp.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20211016
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Chickens
MH  - *Egg Hypersensitivity/diagnosis
MH  - Female
MH  - Humans
MH  - Immunoglobulin E
MH  - Japan/epidemiology
MH  - *Quality of Life
OTO - NOTNLM
OT  - Complete elimination
OT  - Egg allergy
OT  - Oral food challenge
OT  - Quality of life
OT  - Systematic review
EDAT- 2021/10/20 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/10/19 05:51
PHST- 2021/05/07 00:00 [received]
PHST- 2021/09/07 00:00 [revised]
PHST- 2021/09/09 00:00 [accepted]
PHST- 2021/10/20 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/10/19 05:51 [entrez]
AID - S1323-8930(21)00125-8 [pii]
AID - 10.1016/j.alit.2021.09.005 [doi]
PST - ppublish
SO  - Allergol Int. 2022 Apr;71(2):221-229. doi: 10.1016/j.alit.2021.09.005. Epub 2021 
      Oct 16.