PMID- 34664851
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 37
DP  - 2021 Sep 17
TI  - Synergistic association of hyperuricemia and hyperhomocysteinemia with chronic 
      kidney disease in middle-aged adults and the elderly population.
PG  - e27202
LID - 10.1097/MD.0000000000027202 [doi]
LID - e27202
AB  - Chronic kidney disease (CKD) is a major global public health issue. Both 
      hyperhomocysteinemia (HHcy) and hyperuricemia are independent risk factors for 
      CKD. In this study, we evaluated the association of HHcy and hyperuricemia with 
      CKD in the middle-aged and elderly populations in Taiwan.In this cross-sectional 
      study, we collected the data of 5910 patients aged >/=50 years after their 
      self-paid health examination at a single medical center. Homocysteine (Hcy) 
      levels were divided into 4 quartiles (Q1, <8.2; Q2, 8.2-9.8; Q3, 9.9-11.7; and 
      Q4, >11.7 muM/L). Renal function was determined using the Chronic Kidney Disease 
      Epidemiology Collaboration equation. Patients were considered to have CKD if 
      their estimated glomerular filtration rate was < 60 mL/min/1.73 m2.The prevalence 
      of CKD significantly increased with the quartiles of uric acid (UA) and Hcy. In 
      multiple logistic regression analysis, the odds ratios (ORs) of CKD increased 
      with the quartiles of Hcy, independent of UA. There was 22.9 in Q4 in the normal 
      serum UA group and 18.3 in the hyperuricemia group compared with Q1 of Hcy. Both 
      hyperuricemia (OR 2.9) and Q4 of Hcy (OR 8.1) were significant independent risk 
      factors for CKD. Furthermore, hyperuricemia and HHcy had significant synergistic 
      association (synergy index, 1.7) with CKD.The ORs of CKD increased with the 
      quartiles of Hcy, independent of hyperuricemia. Hyperuricemia and HHcy had 
      synergistic association with CKD.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Liu, Peng-Tzu
AU  - Liu PT
AUID- ORCID: 0000-0001-8471-2109
AD  - Department of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 
      Taiwan.
FAU - Chen, Jong-Dar
AU  - Chen JD
AD  - Department of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, 
      Taiwan.
AD  - School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Correlation of Data
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/epidemiology/*etiology
MH  - Hyperuricemia/epidemiology/*etiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/*complications/epidemiology
MH  - Taiwan/epidemiology
PMC - PMC8448071
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2021/10/20 06:00
MHDA- 2021/10/26 06:00
PMCR- 2021/09/17
CRDT- 2021/10/19 10:29
PHST- 2021/04/30 00:00 [received]
PHST- 2021/08/26 00:00 [accepted]
PHST- 2021/10/19 10:29 [entrez]
PHST- 2021/10/20 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/09/17 00:00 [pmc-release]
AID - 00005792-202109170-00027 [pii]
AID - MD-D-21-03355 [pii]
AID - 10.1097/MD.0000000000027202 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Sep 17;100(37):e27202. doi: 
      10.1097/MD.0000000000027202.