PMID- 34666468
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211021
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 56
IP  - 10
DP  - 2021 Oct 7
TI  - [Different concentrations of specialized pro-resolving mediators in eosinophilic 
      and non-eosinophilic chronic rhinosinusitis with nasal polyps].
PG  - 1073-1079
LID - 10.3760/cma.j.cn115330-20210419-00212 [doi]
AB  - Objective: To investigate the difference of concentrations of specialized 
      pro-resolving mediators (SPMs) derived from fatty acids in eosinophilic chronic 
      rhinosinusitis with nasal polyps (ECRSwNP) and non-eosinophilic chronic 
      rhinosinusitis with nasal polyps (nECRSwNP). Methods: A total of 36 patients with 
      bilateral chronic rhinosinusitis with nasal polyps (CRSwNP) who underwent 
      endoscopic nasal surgeries in Peking Union Medical College Hospital from May 2019 
      to September 2020 were enrolled, including 27 males and 9 females, with the age 
      from 13 to 67 years. There were 23 cases of ECRSwNP and 13 cases of nECRSwNP. At 
      the same time, 12 control subjects were enrolled. The concentrations of multiple 
      SPMs, including lipoxins (LXA(4) and LXB(4)), resolvins (RvD(1), RvD(2), RvD(3), 
      RvD(5) and RvE(1)), protectins (PDX) and maresins (Mar-1) in nasal polyps with 
      different histological subtypes and normal nasal mucosa were analyzed using 
      liquid chromatography-tandem mass spectrometry. The concentrations of SPMs 
      between groups were compared using Mann-Whitney U test. Spearman's rank 
      correlation coefficient was used to measure the correlation between the 
      concentrations of SPMs in nasal polyps and tissue eosinophil counts. Results: The 
      concentrations of RvD(2), RvD(3), RvD(5), LXA(4), LXB(4), Mar-1 and PDX in 
      ECRSwNP group were significantly higher than that in controls (Z value was 
      -2.276, -2.313, -3.371, -2.094, -2.051, -3.104 and -2.294, respectively, all 
      P<0.05). The concentrations of RvD(2), RvD(5), Mar-1 and PDX in ECRSwNP group 
      were significantly higher than those in nECRSwNP group (Z value was -2.175, 
      -2.289, -2.243 and -2.124, respectively, all P<0.05). There was no significant 
      difference in all these SPMs between nECRSwNP and controls (all P>0.05). The 
      concentrations of RvD(2), RvD(3), RvD(5), LXB(4), Mar-1 and PDX in nasal polyps 
      correlated positively with tissue eosinophil counts (r value was 0.443, 0.436, 
      0.371, 0.502, 0.340 and 0.386, respectively, all P<0.05). Conclusions: A varienty 
      of SPMs are elevated in ECRSwNP. Dysregulation of fatty acid metabolism might 
      play an important role in the chronic inflammation of ECRSwNP.
FAU - Zhu, Z Z
AU  - Zhu ZZ
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Wang, W Q
AU  - Wang WQ
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Han, J B
AU  - Han JB
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Wang, L
AU  - Wang L
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
FAU - Lyu, W
AU  - Lyu W
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Peking Union Medical 
      College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical 
      College, Beijing 100730, China.
LA  - chi
GR  - 82071027/National Natural Science Foundation of China/
GR  - 7202162/Beijing Municipal Natural Science Foundation/
GR  - 2019XK320034/Non-profit Central Research Institute Fund of Chinese Academy of 
      Medical Sciences/
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Mucosa/pathology
MH  - *Nasal Polyps/complications/pathology
MH  - *Rhinitis/complications/pathology
MH  - *Sinusitis/complications/pathology
MH  - Young Adult
EDAT- 2021/10/21 06:00
MHDA- 2023/02/25 06:00
CRDT- 2021/10/20 04:14
PHST- 2021/10/20 04:14 [entrez]
PHST- 2021/10/21 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
AID - 10.3760/cma.j.cn115330-20210419-00212 [doi]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Oct 7;56(10):1073-1079. doi: 
      10.3760/cma.j.cn115330-20210419-00212.