PMID- 34666862
OWN - NLM
STAT- MEDLINE
DCOM- 20230209
LR  - 20230209
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 50
IP  - 1
DP  - 2023 Jan
TI  - Vertebral to Basilar Thrombus Migration Post Intravenous Thrombolysis.
PG  - 119-122
LID - 10.1017/cjn.2021.237 [doi]
AB  - Recombinant tissue plasminogen activator improves outcomes in acute ischemic 
      stroke. Alteplase may result in thrombus migration (TM) distally to a critical 
      arterial supply that can worsen perfusion to eloquent brain tissue. 
      Alteplase-related stroke recanalization and clot migration in vertebral artery 
      (VA) occlusion whereby the clot migrates to the basilar artery (BA) may be 
      harmful. We identified seven subjects with isolated symptomatic vertebral 
      occlusion. Two cases suffered early neurologic deterioration due to TM from VA to 
      BA following alteplase. Precautionary transfer to thrombectomy centers may be 
      warranted in alteplase-treated symptomatic VA occlusions in case of migration to 
      basilar occlusion.
FAU - Banerjee, Ankur
AU  - Banerjee A
AD  - Department of Medicine, Division of Neurology, University of Alberta, Edmonton, 
      Canada.
FAU - Marzoughi, Sina
AU  - Marzoughi S
AUID- ORCID: 0000-0003-4802-2391
AD  - Department of Medicine, Division of Neurology, University of British Columbia, 
      Vancouver, Canada.
FAU - Ohara, Tomoyuki
AU  - Ohara T
AD  - Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
AD  - Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, 
      Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 
      Calgary, Canada.
FAU - Horn, MacKenzie
AU  - Horn M
AUID- ORCID: 0000-0002-1472-3977
AD  - Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, 
      Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 
      Calgary, Canada.
FAU - Zerna, Charlotte
AU  - Zerna C
AUID- ORCID: 0000-0001-5969-8990
AD  - Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, 
      Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 
      Calgary, Canada.
FAU - Menon, Bijoy K
AU  - Menon BK
AD  - Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, 
      Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 
      Calgary, Canada.
FAU - Demchuk, Andrew M
AU  - Demchuk AM
AD  - Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, 
      Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 
      Calgary, Canada.
LA  - eng
PT  - Journal Article
DEP - 20211020
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - 0 (Fibrinolytic Agents)
SB  - IM
MH  - Humans
MH  - Tissue Plasminogen Activator/therapeutic use
MH  - *Ischemic Stroke/drug therapy
MH  - *Endovascular Procedures
MH  - *Stroke/drug therapy
MH  - *Thrombosis
MH  - Thrombectomy
MH  - Basilar Artery
MH  - *Arterial Occlusive Diseases
MH  - Thrombolytic Therapy
MH  - Treatment Outcome
MH  - Fibrinolytic Agents/therapeutic use
OTO - NOTNLM
OT  - Endovascular therapy
OT  - Posterior circulation
OT  - Stroke
OT  - Thrombus migration
EDAT- 2021/10/21 06:00
MHDA- 2023/02/10 06:00
CRDT- 2021/10/20 05:47
PHST- 2021/10/21 06:00 [pubmed]
PHST- 2023/02/10 06:00 [medline]
PHST- 2021/10/20 05:47 [entrez]
AID - S0317167121002377 [pii]
AID - 10.1017/cjn.2021.237 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2023 Jan;50(1):119-122. doi: 10.1017/cjn.2021.237. Epub 2021 
      Oct 20.