PMID- 34666904
OWN - NLM
STAT- MEDLINE
DCOM- 20220217
LR  - 20220217
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 158
IP  - 3
DP  - 2022 Feb 11
TI  - Diffuse alveolar hemorrhage in a patient with anti-neutrophil cytoplasm 
      antibody-associated vasculitis successfully treated with immunoadsorption 
      combined with methylprednisolone.
PG  - 133-136
LID - S0025-7753(21)00535-2 [pii]
LID - 10.1016/j.medcli.2021.08.004 [doi]
AB  - INTRODUCTION: Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis 
      (AAV) is a rare and life-threatening autoimmune disease. Immunoadsorption (IA) is 
      a potential approach in treating AAV. PATIENTS AND METHODS: A 76-year-old male 
      patient was admitted with hemoptysis and oliguria, progressed rapidly into 
      pulmonary hemorrhaging, acute kidney damage, and multi-organ failure. He was 
      diagnosed as MPO-ANCA-positive vasculitis by immunological detection and kidney 
      biopsy in the case report. IA combined with methylprednisolone to induce and 
      alleviate the disease effectively, and cyclophosphamide (0.2g every other day, a 
      total of 1g for the first time, after the patients tolerated, 10mg/kg every 3 
      weeks for 6 months in total) combined with prednisone for maintenance therapy. 
      RESULTS AND DISCUSSION: Although both kidneys suffered severe deterioration 
      requiring long-term hemodialysis replacement therapy, their pulmonary function 
      was restored. Furthermore, clinical and serological symptoms of the disease were 
      successfully controlled. Consequently, IA treatment may quickly remove IgG and 
      ANCA to efficiently control clinical symptoms, especially in patients presenting 
      with alveolar hemorrhaging and acute renal failure.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Jin, Shanshan
AU  - Jin S
AD  - Department of Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou 
      Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, 
      China. Electronic address: 1228346305@qq.com.
FAU - Wang, Danqiong
AU  - Wang D
AD  - Department of Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou 
      Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, 
      China.
FAU - Luo, Jian
AU  - Luo J
AD  - Department of Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou 
      Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, 
      China.
FAU - Zhang, Weiwen
AU  - Zhang W
AD  - Department of Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou 
      Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, 
      China.
FAU - Wu, Meng
AU  - Wu M
AD  - Department of Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou 
      Medical University, Quzhou People's Hospital, Quzhou 324000, Zhejiang Province, 
      China.
LA  - eng
LA  - spa
PT  - Case Reports
DEP - 20211017
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Aged
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications/drug 
      therapy
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Cytoplasm
MH  - Hemorrhage/chemically induced/therapy
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Methylprednisolone/therapeutic use
OTO - NOTNLM
OT  - AAV
OT  - ANCA
OT  - Case report
OT  - Immunoadsorption
OT  - Inmunoadsorcion
OT  - Intercambio de plasma
OT  - Plasma exchange
OT  - Presentacion de caso
OT  - VAA
EDAT- 2021/10/21 06:00
MHDA- 2022/02/19 06:00
CRDT- 2021/10/20 05:49
PHST- 2021/05/10 00:00 [received]
PHST- 2021/08/02 00:00 [revised]
PHST- 2021/08/06 00:00 [accepted]
PHST- 2021/10/21 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2021/10/20 05:49 [entrez]
AID - S0025-7753(21)00535-2 [pii]
AID - 10.1016/j.medcli.2021.08.004 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2022 Feb 11;158(3):133-136. doi: 10.1016/j.medcli.2021.08.004. 
      Epub 2021 Oct 17.