PMID- 34667494
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 1989-5488 (Print)
IS  - 1989-5488 (Electronic)
IS  - 1989-5488 (Linking)
VI  - 13
IP  - 10
DP  - 2021 Oct
TI  - Efficacy and safety of two artificial saliva-based polymers containing 0.1% 
      pilocarpine for treatment of xerostomia: A randomized clinical pilot trial.
PG  - e994-e1000
LID - 10.4317/jced.58415 [doi]
AB  - BACKGROUND: Topical agents are the mainstay in the treatment of xerostomia, a 
      common complaint most frequently associated with salivary dysfunction. This study 
      aimed to compared the efficacy and safety for xerostomia treatment of 2 
      artificial saliva preparations containing 0.1% pilocarpine, and, either sodium 
      carboxymethylcellulose (SCMC), or, sodium polyacrylate (SPA). MATERIAL AND 
      METHODS: Thirty-one xerostomia patients were randomly allocated into either a 
      SCMC-treated group (15 patients), or, a SPA-treated group (16 patients). The 
      formulations were taken 0.5 ml, 4 times daily for 6 weeks and double-blinded 
      assessed before and after treatments using Xerostomia Inventory (XI) and Clinical 
      Oral Dryness Score (CODs). Unstimulated and stimulated whole salivary flow rates 
      were measured. RESULTS: After treatment, the SCMC-treated group had significantly 
      lower CODs and higher unstimulated and stimulated whole salivary flow rates 
      (p<0.001, p=0.035, and p=0.013, respectively), while the SPA-treated group showed 
      significantly lower CODs only (p=0.004). In contrast, SCMC-treated and 
      SPA-treated groups at the 6th week after treatments showed non-significant 
      differences in all assessments (p>0.05, all). Some adverse events (AEs) were 
      reported, e.g., burning tongue, dizziness and watery eyes, but no severe AEs. 
      CONCLUSIONS: This randomized controlled pilot trial demonstrated superior 
      efficacy of SCMC-formula over a SPA-formula after 6 weeks of xerostomia 
      treatment. These formulations with topical pilocarpine proved safe in clinical 
      use with minimal reported AE. Key words:Xerostomia, artificial saliva, sodium 
      carboxymethylcellulose, sodium polyacrylate, pilocarpine.
CI  - Copyright: (c) 2021 Medicina Oral S.L.
FAU - Sarideechaigul, Wilairat
AU  - Sarideechaigul W
AD  - Department of Oral Biomedical Science, Faculty of Dentistry, Khon Kaen 
      University, Khon Kaen 40002, Thailand.
AD  - Neuroscience Research and Development Group, Khon Kaen University, Khon Kaen 
      40002, Thailand.
FAU - Priprem, Aroonsri
AU  - Priprem A
AD  - Faculty of Pharmacy, Mahasarakham University, Mahasarakham 44150, Thailand.
AD  - Melatonin Research Group, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Limsitthichaikoon, Sucharat
AU  - Limsitthichaikoon S
AD  - Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, 
      Pathum Thani 12000, Thailand.
FAU - Phothipakdee, Pensri
AU  - Phothipakdee P
AD  - Department of Oral Biomedical Science, Faculty of Dentistry, Khon Kaen 
      University, Khon Kaen 40002, Thailand.
FAU - Chaijit, Rajda
AU  - Chaijit R
AD  - Department of Preventive Dentistry, Faculty of Dentistry, Khon Kaen University, 
      Khon Kaen 40002, Thailand.
FAU - Jorns, Teekayu P
AU  - Jorns TP
AD  - Department of Oral Biomedical Science, Faculty of Dentistry, Khon Kaen 
      University, Khon Kaen 40002, Thailand.
AD  - Neuroscience Research and Development Group, Khon Kaen University, Khon Kaen 
      40002, Thailand.
FAU - Lungruammit, Nopphakhun
AU  - Lungruammit N
AD  - Dental Student, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, 
      Thailand.
FAU - Chaiya, Krittiporn
AU  - Chaiya K
AD  - Dental Student, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, 
      Thailand.
LA  - eng
PT  - Journal Article
DEP - 20211001
PL  - Spain
TA  - J Clin Exp Dent
JT  - Journal of clinical and experimental dentistry
JID - 101603132
PMC - PMC8501859
COIS- Conflicts of interest The authors declare that they have no conflicts of 
      interest.
EDAT- 2021/10/21 06:00
MHDA- 2021/10/21 06:01
PMCR- 2021/10/01
CRDT- 2021/10/20 06:44
PHST- 2021/03/19 00:00 [received]
PHST- 2021/05/24 00:00 [accepted]
PHST- 2021/10/20 06:44 [entrez]
PHST- 2021/10/21 06:00 [pubmed]
PHST- 2021/10/21 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - 58415 [pii]
AID - 10.4317/jced.58415 [doi]
PST - epublish
SO  - J Clin Exp Dent. 2021 Oct 1;13(10):e994-e1000. doi: 10.4317/jced.58415. 
      eCollection 2021 Oct.