PMID- 34668513
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220609
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 61
IP  - 6
DP  - 2022 May 30
TI  - Assessing the role for nailfold videocapillaroscopy in interstitial lung disease 
      classfication: a systematic review and meta-analysis.
PG  - 2221-2234
LID - 10.1093/rheumatology/keab772 [doi]
AB  - OBJECTIVES: The nailfold videocapillaroscopy (NVC) has been known to assist with 
      interstitial lung disease (ILD) classification. However, evidence on its 
      diagnostic efficacy is limited, particularly in some connective tissue 
      disease-related interstitial lung diseases (CTD-ILD), and in interstitial 
      pneumonia with autoimmune features (IPAF). This study aimed to address this 
      limitation by conducting a meta-analysis on the efficacy of the NVC in ILD 
      subgroups of CTD-ILD, IPAF and idiopathic pulmonary fibrosis (IPF). METHODS: 
      MEDLINE, EMBASE, CENTRAL were screened from inception to December 2020 according 
      to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 
      guidelines. Studies that report prevalence of nailfold abnormalities (NVC+) in 
      CTD-ILD, IPAF and IPF cohorts were included. Data were presented as prevalence 
      ratio (PR) with 95% CI using a random-effects model. Quality of evidence was 
      assessed using GRADE criteria. RESULTS: Twenty-one studies were eligible. 
      Prevalence of NVC+ was highest in CTD-ILD; PR (95 CI%) 80.4% (74.3%, 85.3%), 
      followed by IPAF; 27.4% (10.9%, 53.7%), and IPF; 13.8% (5.7%, 29.9%). Late 
      scleroderma pattern was the most prevalent nailfold pattern; 40.4% (28.1%, 54.1%) 
      in our CTD-ILD cohort. Quality of evidence was low for CTD-ILD, IPAF and IPF 
      cohorts, moderate for the late scleroderma pattern cohort. CONCLUSION: NVC can 
      increase the diagnostic accuracy of ILD when used in a multi-disciplinary 
      setting, and appears to have greatest utility in CTD-ILD, followed by IPAF and 
      IPF. The Late Scleroderma Pattern was the most frequent nailfold capillary 
      pattern in SSc-ILD. Future research will allow for greater understanding of the 
      prognostic value of the NVC in ILD.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Umashankar, Eshwar
AU  - Umashankar E
AUID- ORCID: 0000-0003-3867-3510
AD  - Faculty of Medicine, University of New South Wales.
FAU - Abdel-Shaheed, Christina
AU  - Abdel-Shaheed C
AD  - School of Public Health, University of Sydney.
FAU - Plit, Marshall
AU  - Plit M
AD  - Faculty of Medicine, University of New South Wales.
AD  - Department of Thoracic Medicine, St Vincent's Hospital.
FAU - Girgis, Laila
AU  - Girgis L
AD  - Faculty of Medicine, University of New South Wales.
AD  - Department of Rheumatology, St Vincent's Hospital, Sydney, New South Wales, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
CIN - Rheumatology (Oxford). 2022 May 30;61(6):2217-2220. PMID: 35199140
MH  - *Connective Tissue Diseases/complications/diagnosis
MH  - Humans
MH  - *Idiopathic Pulmonary Fibrosis
MH  - *Lung Diseases, Interstitial/diagnostic imaging
MH  - Microscopic Angioscopy
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - connective tissue disease
OT  - idiopathic pulmonary fibrosis
OT  - interstitial lung disease
OT  - interstitial pneumonia with autoimmune features
OT  - nailfold videocapillaroscopy
EDAT- 2021/10/21 06:00
MHDA- 2022/06/03 06:00
CRDT- 2021/10/20 08:47
PHST- 2021/05/19 00:00 [received]
PHST- 2021/09/19 00:00 [revised]
PHST- 2021/10/09 00:00 [accepted]
PHST- 2021/10/21 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2021/10/20 08:47 [entrez]
AID - 6404612 [pii]
AID - 10.1093/rheumatology/keab772 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2022 May 30;61(6):2221-2234. doi: 
      10.1093/rheumatology/keab772.