PMID- 34668936
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220322
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Linking)
VI  - 33
IP  - 12
DP  - 2021 Nov 25
TI  - Identification of microenvironmental niches for hematopoietic stem cells and 
      lymphoid progenitors-bone marrow fibroblastic reticular cells with salient 
      features.
PG  - 821-826
LID - 10.1093/intimm/dxab092 [doi]
AB  - Most lineages of blood cells, including immune cells, are generated from 
      hematopoietic stem cells (HSCs) in bone marrow throughout adult life. Since HSCs 
      cannot expand on their own, they require and contact the special 
      microenvironments, termed niches for their maintenance. HSC niches comprise 
      supportive cells that provide adjacent HSCs with critical signals, including 
      cytokines. Although bone marrow microenvironments have been thought to be 
      complex, recent studies have demonstrated that the bone marrow-specific 
      population of fibroblastic reticular cells with long processes, termed CXC 
      chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, which overlap 
      strongly with leptin receptor (LepR)-expressing (LepR+) cells, is the major 
      cellular component of niches for HSCs and lymphoid progenitors. CAR cells have 
      salient features, expressing much higher levels of critical HSC niche factors 
      than any other cell populations and function as self-renewing mesenchymal stem 
      cells. Human counterpart of CAR cells is present and affected in diseases, 
      including leukemia. Foxl1+ telocytes recently identified as the niche for 
      intestinal stem cells share some features with CAR cells, suggesting that CAR 
      cells might serve as a prototype for fibroblastic reticular cells creating niche 
      for long-lived cells, including tissue stem cells and memory lymphocytes. These 
      findings provided the basis for future mechanistic studies on the cross-talk 
      between hematopoietic cells and microenvironments in both health and disease.
CI  - (c) The Japanese Society for Immunology. 2021. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Omatsu, Yoshiki
AU  - Omatsu Y
AD  - Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of 
      Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier 
      Research Center, Osaka University, Osaka, Japan.
FAU - Nagasawa, Takashi
AU  - Nagasawa T
AD  - Laboratory of Stem Cell Biology and Developmental Immunology, Graduate School of 
      Frontier Biosciences and Graduate School of Medicine, WPI Immunology Frontier 
      Research Center, Osaka University, Osaka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
SB  - IM
MH  - Animals
MH  - Bone Marrow/*immunology
MH  - Fibroblasts/*immunology
MH  - Hematopoietic Stem Cells/*immunology
MH  - Humans
MH  - Stem Cell Niche/*immunology
OTO - NOTNLM
OT  - B cells
OT  - HSCs
OT  - lymphopoiesis
OT  - mesenchymal stem cells
OT  - microenvironments
EDAT- 2021/10/21 06:00
MHDA- 2022/03/23 06:00
CRDT- 2021/10/20 12:24
PHST- 2021/09/20 00:00 [received]
PHST- 2021/10/19 00:00 [accepted]
PHST- 2021/10/21 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2021/10/20 12:24 [entrez]
AID - 6406389 [pii]
AID - 10.1093/intimm/dxab092 [doi]
PST - ppublish
SO  - Int Immunol. 2021 Nov 25;33(12):821-826. doi: 10.1093/intimm/dxab092.