PMID- 34669508
OWN - NLM
STAT- MEDLINE
DCOM- 20220211
LR  - 20220211
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 19
IP  - 10
DP  - 2021 Dec
TI  - Hyperhomocysteinemia Promotes Carotid Artery Damage in Newly Diagnosed Type 2 
      Diabetic Patients Without Hypercholesterolemia.
PG  - 575-580
LID - 10.1089/met.2021.0031 [doi]
AB  - Background: The relationship between serum homocysteine levels and carotid artery 
      damage in subjects with newly diagnosed type 2 diabetes mellitus remains unclear. 
      The effect of hyperhomocysteinemia (HHCY) on carotid artery damage in patients 
      with different cholesterol levels needs to be further investigated. Methods: In 
      total 456 newly diagnosed type 2 diabetes from Beijing Chaoyang Hospital were 
      recruited into the study. Patients were divided into four groups according to the 
      levels of serum homocysteine and cholesterol. Carotid artery damage was defined 
      as thickened intima-media and/or plaque formation. Results: In all the subjects, 
      80.2% patients had HHCY. The incidence of carotid artery injury was significantly 
      lower in diabetic patients with normal homocysteine levels and 
      nonhypercholesterolemia. Spearman correlation analysis showed homocysteine was 
      positively correlated with free fatty acid and negatively correlated with glucose 
      metabolism parameters. Logistic regression showed HHCY was correlated with 
      carotid artery injury after adjusting for traditional cerebrovascular risk 
      factors in type 2 diabetes without hypercholesterolemia (odds risk = 3.197, 
      P = 0.022). Whereas HHCY was not associated with carotid artery injury in either 
      total study population or hypercholesterolemia subgroup. Conclusions: HHCY was 
      correlated with carotid artery damage in newly diagnosed type 2 diabetic subjects 
      without hypercholesterolemia. How to improve the adverse vascular outcomes 
      mediated by HHCY for diabetic patients needed further investigation.
FAU - Liu, Man
AU  - Liu M
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Heng
AU  - Zhang H
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Guang
AU  - Wang G
AUID- ORCID: 0000-0003-4868-9786
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211020
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Carotid Arteries/diagnostic imaging
MH  - Carotid Intima-Media Thickness
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/epidemiology
MH  - Homocysteine
MH  - Humans
MH  - *Hypercholesterolemia/complications/diagnosis/epidemiology
MH  - *Hyperhomocysteinemia/complications/diagnosis/epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - carotid artery damage
OT  - free fatty acid
OT  - hypercholesterolemia
OT  - hyperhomocysteinemia
OT  - newly diagnosed type 2 diabetes mellitus
EDAT- 2021/10/21 06:00
MHDA- 2022/02/12 06:00
CRDT- 2021/10/20 17:17
PHST- 2021/10/21 06:00 [pubmed]
PHST- 2022/02/12 06:00 [medline]
PHST- 2021/10/20 17:17 [entrez]
AID - 10.1089/met.2021.0031 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2021 Dec;19(10):575-580. doi: 10.1089/met.2021.0031. 
      Epub 2021 Oct 20.