PMID- 34670337
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 1930-8264 (Electronic)
IS  - 1930-8264 (Linking)
VI  - 108
IP  - 5
DP  - 2018 Sep 1
TI  - Toenail Changes in Patients with Diabetes Mellitus with and Without 
      Onychomycosis.
PG  - 370-374
LID - 10.7547/17-006 [doi]
AB  - BACKGROUND: Diabetes mellitus is a predisposing factor for onychomycosis (OM). A 
      high frequency of nonfungal onychodystrophy (OD) is also alleged, although 
      information on the prevalence of specific nail changes is scant. We evaluated the 
      prevalence and types of nail changes in a cohort of diabetic patients with fungal 
      and nonfungal OD. METHODS: During a 6-month period, inpatients with diabetes 
      mellitus were screened for foot and toenail changes. Demographic, social, and 
      clinical data were recorded, as was information concerning foot and toenail care. 
      Fungal infection was confirmed by mycologic examination and by histologic 
      analysis of nail clippings. RESULTS: Of the 82 patients included, 65 (79.3%) had 
      nail changes, and 34 of these 65 patients (52.3%) were diagnosed as having OM. 
      The most frequently observed nail signs were subungual hyperkeratosis, 
      onycholysis, yellow discoloration, and splinter hemorrhages, each seen in more 
      than 25% of the patients. Tinea pedis and superficial pseudoleukonychia were 
      observed more frequently in the OM group (P < .05). Conversely, prominent 
      metatarsal heads and history of nail trauma were more frequent in patients with 
      nonfungal OD (P < .05). CONCLUSIONS: Physicians who care for diabetic patients 
      should not ignore nail changes. Fungal and nonfungal OD are common and should be 
      addressed in the global evaluation of the feet to help prevent breaks in the skin 
      barrier and subsequent bacterial infections and ulcers.
CI  - Copyright (c)2018 by the American Podiatric Medical Association.
FAU - Cunha, Nelia
AU  - Cunha N
FAU - Galhardas, Celia
AU  - Galhardas C
FAU - Apetato, Margarida
AU  - Apetato M
FAU - Lencastre, Andre
AU  - Lencastre A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Podiatr Med Assoc
JT  - Journal of the American Podiatric Medical Association
JID - 8501423
SB  - IM
EDAT- 2018/09/01 00:00
MHDA- 2018/09/01 00:01
CRDT- 2021/10/21 01:01
PHST- 2021/10/21 01:01 [entrez]
PHST- 2018/09/01 00:00 [pubmed]
PHST- 2018/09/01 00:01 [medline]
AID - 152406 [pii]
AID - 10.7547/17-006 [doi]
PST - ppublish
SO  - J Am Podiatr Med Assoc. 2018 Sep 1;108(5):370-374. doi: 10.7547/17-006.