PMID- 34671251 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211022 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 12 DP - 2021 TI - Application of MAT Methodology in the Evaluation of Prescribing Adherence to Clinical Practice Guidelines for Secondary Prevention of Coronary Heart Disease in Post-Acute Coronary Syndrome Patients in Kuwait. PG - 647674 LID - 10.3389/fphar.2021.647674 [doi] LID - 647674 AB - Quantification of prescribers' adherence to evidence-based guidelines can be used as an outcome measure to assess the impact of services on the quality of medication use. Additionally, it can help in reducing inappropriate interventions and ensure that high-quality care is provided to patients. This study aimed to evaluate prescribing practices for secondary prevention of coronary heart disease (CHD) in post-acute coronary syndromes (ST-elevation myocardial infarction [STEMI] or non-ST elevation acute coronary syndrome [NSTEACS]) patients using two medication assessment tools (MATs) at secondary and tertiary health-care settings in Kuwait. Both MATs were developed and validated based on the relevant guidelines issued by the European Society of Cardiology and the American College of Cardiology/American Heart Association. A quantitative cross-sectional multicenter study was conducted on 460 patients' medical records collected randomly from six health-care facilities in Kuwait. Application of MAT(STEMI) on 232 patients' medication records (with 85.9% applicability) resulted in intermediate overall adherence (69.8%; 95% CI: 67.6-72.0). Application of MAT(NSTEACS) on 228 patients' medication records (with applicability 83.2%) resulted in intermediate overall adherence (73.3%; 95% CI: 70.5-76.0). There was no significant difference between the percentages of overall adherence among patients managed post-NSTEACS compared to those managed post-STEMI (p = 0.05). Multivariable logistic regression analysis revealed that the overall adherence to the MAT(STEMI) criteria was significantly higher among the specialized cardiac centers than among the general hospitals (OR: 1.6; 95% CI: 1.1-2.3; p = 0.02). The overall adherence to the MAT(NSTEACS) criteria was found to be significantly lower among non-Kuwaitis than among Kuwaitis (OR: 0.6; 95% CI: 0.5-0.9; p = 0.01) and patients with a serum LDL >/=1.8 mmol/L than those with a serum LDL-C < 1.8 mmol/L (OR: 0.5; 95% CI: 0.4-0.7; p < 0.001). The present findings revealed that both MATs were useful tools in identifying the standard of clinical performances and highlighting areas for improvement regarding secondary prevention of CHD in post-acute coronary syndrome patients. CI - Copyright (c) 2021 Al-Taweel and Awad. FAU - Al-Taweel, Dalal AU - Al-Taweel D AD - Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, Kuwait City, Kuwait. FAU - Awad, Abdelmoneim AU - Awad A AD - Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University, Kuwait City, Kuwait. LA - eng PT - Journal Article DEP - 20211004 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC8520912 OTO - NOTNLM OT - Non ST Elevation Myocardial Infarction OT - ST Elevation Myocardial Infarction OT - guideline adherence OT - medication adherence OT - practice guideline COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/10/22 06:00 MHDA- 2021/10/22 06:01 PMCR- 2021/10/04 CRDT- 2021/10/21 06:07 PHST- 2020/12/30 00:00 [received] PHST- 2021/08/23 00:00 [accepted] PHST- 2021/10/21 06:07 [entrez] PHST- 2021/10/22 06:00 [pubmed] PHST- 2021/10/22 06:01 [medline] PHST- 2021/10/04 00:00 [pmc-release] AID - 647674 [pii] AID - 10.3389/fphar.2021.647674 [doi] PST - epublish SO - Front Pharmacol. 2021 Oct 4;12:647674. doi: 10.3389/fphar.2021.647674. eCollection 2021.