PMID- 34671491
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2090-214X (Print)
IS  - 2090-2158 (Electronic)
VI  - 2021
DP  - 2021
TI  - Evaluation of Human Leukocyte Antigen Class I and Class II in End-Stage Renal 
      Disease Occurrence in Indonesian Transplantation Patients.
PG  - 4219822
LID - 10.1155/2021/4219822 [doi]
LID - 4219822
AB  - BACKGROUND: Genetic studies of end-stage renal disease (ESRD), including those of 
      human leukocyte antigen (HLA) genes, have been reported in several populations 
      but have not yet been evaluated in Indonesia. Some studies have reported that 
      these genes had a substantial role in ESRD. This study aims to analyze the 
      association between HLA genes and ESRD within the Indonesian community. METHOD: A 
      retrospective study to investigate HLA class I and II alleles to find out the 
      distribution of HLA-A, -B, -C, -DPB1, -DQB1, and -DRB1 in renal transplant 
      recipients and to ascertain their role in susceptibility to ESRD was performed on 
      totally 149 subjects, consisting of 69 ESRD patients and 80 healthy controls. HLA 
      typing was determined using Luminex techniques. The allele and haplotype 
      frequencies were compared between ESRD patients and controls. RESULT: 
      High-frequency alleles were HLA-A *24 (43.6%), B *15 (38.2%), C *08 (30.8%), DRB1 *12 
      (47.3%), DQB1 *03 (50.6%), and DPB1 *13 (22.5%). HLA-A *24 (p=0.01) and HLA-B *35 
      (p=0.02) were associated with a protective effect, with OR 0.537 (95%CI 
      0.34-0.86) and 0.316 (95%CI 0.11-0.88), respectively. There were some two-locus 
      haplotypes associated with susceptibility to ESRD, such as B *15-DRB1 *12, 
      B *13-DRB1 *15, A *02-B *15, A *02-C *08, and B *13-DQB1 *05. HLA-A *02-B *15-DRB1 *12 and 
      A *24-B *13-DRB1 *15 appear to be associated with susceptibility to ESRD. 
      CONCLUSION: The allele groups of HLA-A *24 and HLA-B *35 are associated with 
      protection from ESRD. Meanwhile, HLA-B *13-DRB1 *15 and A *24-B *13-DRB1 *15 are the 
      most frequent HLAs associated with ESRD in two-locus and three-locus haplotype, 
      respectively.
CI  - Copyright (c) 2021 Hani Susianti et al.
FAU - Susianti, Hani
AU  - Susianti H
AUID- ORCID: 0000-0003-4019-9109
AD  - Clinical Pathology Departement, Dr. Saiful Anwar General Hospital, Faculty of 
      Medicine, Universitas Brawijaya, Malang, Indonesia.
FAU - Djatmiko, Dwi Priyadi
AU  - Djatmiko DP
AUID- ORCID: 0000-0002-7110-4961
AD  - Clinical Pathology Departement, Dr. Saiful Anwar General Hospital, Faculty of 
      Medicine, Universitas Brawijaya, Malang, Indonesia.
FAU - Adi Widana, I Komang
AU  - Adi Widana IK
AUID- ORCID: 0000-0002-3360-1107
AD  - Clinical Pathology Departement, Dr. Saiful Anwar General Hospital, Faculty of 
      Medicine, Universitas Brawijaya, Malang, Indonesia.
FAU - Tandio, Deasy Ayuningtyas
AU  - Tandio DA
AUID- ORCID: 0000-0001-7847-2831
AD  - Clinical Pathology Departement, Dr. Saiful Anwar General Hospital, Faculty of 
      Medicine, Universitas Brawijaya, Malang, Indonesia.
FAU - Sutrisnani, Catur Suci
AU  - Sutrisnani CS
AUID- ORCID: 0000-0002-5306-6500
AD  - Clinical Pathology Departement, Dr. Saiful Anwar General Hospital, Faculty of 
      Medicine, Universitas Brawijaya, Malang, Indonesia.
FAU - Wahono, Singgih Pudjo
AU  - Wahono SP
AUID- ORCID: 0000-0002-3965-3266
AD  - Clinical Pathology Departement, Dr. Saiful Anwar General Hospital, Faculty of 
      Medicine, Universitas Brawijaya, Malang, Indonesia.
FAU - Puspitawati, Ira
AU  - Puspitawati I
AUID- ORCID: 0000-0001-6363-6303
AD  - Clinical Pathology Departement, Dr. Sardjito General Hospital, Faculty of 
      Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 
      Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20211011
PL  - United States
TA  - Int J Nephrol
JT  - International journal of nephrology
JID - 101546753
PMC - PMC8523260
COIS- The authors declare no conflicts of interest.
EDAT- 2021/10/22 06:00
MHDA- 2021/10/22 06:01
PMCR- 2021/10/11
CRDT- 2021/10/21 06:10
PHST- 2021/04/19 00:00 [received]
PHST- 2021/08/31 00:00 [revised]
PHST- 2021/09/14 00:00 [accepted]
PHST- 2021/10/21 06:10 [entrez]
PHST- 2021/10/22 06:00 [pubmed]
PHST- 2021/10/22 06:01 [medline]
PHST- 2021/10/11 00:00 [pmc-release]
AID - 10.1155/2021/4219822 [doi]
PST - epublish
SO  - Int J Nephrol. 2021 Oct 11;2021:4219822. doi: 10.1155/2021/4219822. eCollection 
      2021.