PMID- 34673041
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20240503
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 288
IP  - Pt 2
DP  - 2022 Feb
TI  - Investigation of antibacterial, antifungal, antibiofilm, antioxidant and 
      anticancer properties of methanol extracts of Salvia marashica Ilcim, Celep & 
      Dogan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal 
      importance.
PG  - 132602
LID - S0045-6535(21)03074-5 [pii]
LID - 10.1016/j.chemosphere.2021.132602 [doi]
AB  - In this study, Antimicrobial, Antifungal and Antibiofilm activity tests on 16 
      bacteria and 2 fungi of Salvia marashica Ilcim, Celep & Dogan and Salvia 
      caespitosa Montbret & Aucher ex Benth species were performed by Agar Well 
      Diffusion and Microdilution methods. Salvia species showed sensitivity with a 
      zone diameter of 12-16 mm. Concentrations of 0.5 mg/ml to 16 mg/ml by the 
      dilution method were used to determine the Minimum inhibited concentration (MIC) 
      and Minimum bactericidal concentration (MBK). The MIC values of the plants are 
      mostly 0.5 mg/ml - 4 mg/ml and MBC values are between 0.5 mg/ml - 8 mg/ml. 
      Antifungal activity findings are remarkable on the species and it has been 
      observed to have very high effects especially on Candida parapsilosis. When the 
      antioxidant research findings are examined; It was observed that Salvia marashica 
      and Salvia caespitosa plants have approximately 75% antioxidant activity at 
      1 mg/ml, and findings mostly directly proportional between concentrations and 
      antioxidant activity capacity were recorded. MCF-7 and HUVEC cell lines were used 
      to investigate anticancer activity properties. In line with the findings, while 
      the IC50 value of Salvia marashica on the MCF-7 Cell line was 0.125 mg/ml, it was 
      1.65 mg/ml in the HUVEC cell line, while the IC50 value of Salvia caespitosa on 
      the MCF-7 Cell line was 0.115 mg/ml in the HUVEC Cell line. It was found to be 
      9.87 mg/ml. It has been proven that both Salvia species have a cytotoxic effect 
      on the MCF-7 Cell line.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Bostanci, Maside Temiz
AU  - Bostanci MT
AD  - Kahramanmaras Sutcu Imam University, Faculty of Science and Literature, 
      Department of Biology, Turkey.
FAU - Bulbul, Ali Savas
AU  - Bulbul AS
AD  - Bayburt University, Faculty of Applied Sciences, Department of Emergency Aid and 
      Disaster ManagementBayburt University, Turkey. Electronic address: 
      alisavasbulbul@bayburt.edu.tr.
FAU - Celik, Ibrahim Seyfettin
AU  - Celik IS
AD  - Kahramanmaras Sutcu Imam University, Faculty of Medicine, Department of Medical 
      Pathology, Turkey.
FAU - Kocabas, Yusuf Ziya
AU  - Kocabas YZ
AD  - Kahramanmaras Sutcu Imam University, Turkoglu Vocational School, Department of 
      Plant and Animal Production, Turkey.
FAU - Burhan, Hakan
AU  - Burhan H
AD  - Sen Research Group, Faculty of Science and Art, Department of Biochemistry, 
      Dumlupinar University, Kutahya, Turkey.
FAU - Bayat, Ramazan
AU  - Bayat R
AD  - Sen Research Group, Faculty of Science and Art, Department of Biochemistry, 
      Dumlupinar University, Kutahya, Turkey.
FAU - Sen, Fatih
AU  - Sen F
AD  - Sen Research Group, Faculty of Science and Art, Department of Biochemistry, 
      Dumlupinar University, Kutahya, Turkey. Electronic address: 
      fatihsen1980@gmail.com.
FAU - Zakariae, Nilofar
AU  - Zakariae N
AD  - Nursing Medical-Surgical Group, Shahid Beheshti University of Medical Science, 
      Tehran, Iran.
FAU - Esmaeili, Roghayeh
AU  - Esmaeili R
AD  - Nursing Medical-Surgical Group, Shahid Beheshti University of Medical Science, 
      Tehran, Iran.
FAU - Jafari, Hedayat
AU  - Jafari H
AD  - Traditional and Complementary Medicine Research Center, Addiction Institute, 
      Mazandaran University of Medical Sciences, Sari, Iran.
FAU - Karimi, Fatemeh
AU  - Karimi F
AD  - Department of Chemical Engineering, Quchan University of Technology, Quchan, 
      9477177870, Iran. Electronic address: fkm024@qiet.ac.ir.
FAU - Karimi-Maleh, Hassan
AU  - Karimi-Maleh H
AD  - Department of Chemical Engineering, Quchan University of Technology, Quchan, 
      9477177870, Iran. Electronic address: h.karimi.maleh@qiet.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20211018
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antifungal Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
ECI - Chemosphere. 2024 May;356:141989. PMID: 38685632
MH  - Anti-Bacterial Agents/pharmacology
MH  - Antifungal Agents/pharmacology
MH  - Antioxidants/pharmacology
MH  - Biofilms
MH  - Methanol
MH  - Plant Extracts/pharmacology
MH  - *Salvia
OTO - NOTNLM
OT  - Antibiofilm
OT  - Antioxidant
OT  - HUVEC
OT  - MCF-7
OT  - Salvia species
EDAT- 2021/10/22 06:00
MHDA- 2021/12/21 06:00
CRDT- 2021/10/21 20:49
PHST- 2021/07/31 00:00 [received]
PHST- 2021/10/07 00:00 [revised]
PHST- 2021/10/16 00:00 [accepted]
PHST- 2021/10/22 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2021/10/21 20:49 [entrez]
AID - S0045-6535(21)03074-5 [pii]
AID - 10.1016/j.chemosphere.2021.132602 [doi]
PST - ppublish
SO  - Chemosphere. 2022 Feb;288(Pt 2):132602. doi: 10.1016/j.chemosphere.2021.132602. 
      Epub 2021 Oct 18.