PMID- 34673082
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 200
DP  - 2021 Dec
TI  - Rodent diet aids and the fallacy of caloric restriction.
PG  - 111584
LID - S0047-6374(21)00156-1 [pii]
LID - 10.1016/j.mad.2021.111584 [doi]
AB  - Understanding the molecular mechanisms of normal aging is a prerequisite to 
      significantly improving human health span. Caloric restriction (CR) can delay 
      aging and has served as a yardstick to evaluate interventions extending life 
      span. However, mice given unlimited access to food suffer severe obesity. Health 
      gains from CR depend on control mice being sufficiently overweight and less obese 
      mouse strains benefit far less from CR. Pharmacologic interventions that increase 
      life span, including resveratrol, rapamycin, nicotinamide mononucleotide and 
      metformin, also reduce body weight. In primates, CR does not delay aging unless 
      the control group is eating enough to suffer from obesity-related disease. Human 
      survival is optimal at a body mass index achievable without CR, and the above 
      interventions are merely diet aids that shouldn't slow aging in healthy weight 
      individuals. CR in humans of optimal weight can safely be declared useless, since 
      there is overwhelming evidence that hunger, underweight and starvation reduce 
      fitness, survival, and quality of life. Against an obese control, CR does, 
      however, truly delay aging through a mechanism laid out in the following tumor 
      suppression theory of aging.
CI  - Copyright (c) 2021 The Author. Published by Elsevier B.V. All rights reserved.
FAU - Wolf, Alexander M
AU  - Wolf AM
AD  - Laboratory for Morphological and Biomolecular Imaging, Faculty of Medicine, 
      Nippon Medical School, Japan. Electronic address: 
      alexander.martin.wolf@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211018
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Senotherapeutics)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Energy Intake/physiology
MH  - Healthy Aging/physiology
MH  - Humans
MH  - Longevity/*drug effects
MH  - Mice
MH  - *Obesity/diet therapy/drug therapy/metabolism/mortality
MH  - Senotherapeutics/*pharmacology
MH  - Survival Analysis
OTO - NOTNLM
OT  - Aging
OT  - Caloric restriction
OT  - Caloric restriction mimetics
OT  - Life span
OT  - Obesity
EDAT- 2021/10/22 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/10/21 20:49
PHST- 2021/03/09 00:00 [received]
PHST- 2021/10/01 00:00 [revised]
PHST- 2021/10/05 00:00 [accepted]
PHST- 2021/10/22 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/10/21 20:49 [entrez]
AID - S0047-6374(21)00156-1 [pii]
AID - 10.1016/j.mad.2021.111584 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2021 Dec;200:111584. doi: 10.1016/j.mad.2021.111584. Epub 2021 
      Oct 18.