PMID- 34673536 OWN - NLM STAT- MEDLINE DCOM- 20211101 LR - 20240404 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 9 IP - 10 DP - 2021 Oct 21 TI - Smartphone-Assisted High-Intensity Interval Training in Inflammatory Rheumatic Disease Patients: Randomized Controlled Trial. PG - e28124 LID - 10.2196/28124 [doi] LID - e28124 AB - BACKGROUND: Patients with inflammatory rheumatic diseases (IRDs) experience disease-related barriers to physical training. Compared with the general population, IRD patients are reported to have reduced maximal oxygen uptake (VO(2max)) and physical activity levels. Supervised high-intensity interval training (HIIT) is documented to counteract the reduced VO(2max) and poor cardiovascular health associated with IRDs. However, supervised HIIT is resource demanding. OBJECTIVE: This study sought to investigate if self-administered 4x4-min HIIT guided by a smartphone app (Myworkout GO) could yield similar HIIT-induced effects as standard 4x4-min HIIT performed under the guidance and supervision of health care professionals. The effects studied were on VO(2max) and health-related quality of life (HRQoL). METHODS: Forty patients (33 female patients, mean age 48 years, SD 12 years; 7 male patients, mean age 52 years, SD 11 years) diagnosed with rheumatoid arthritis, spondyloarthritis, or systemic lupus erythematosus were randomized to a supervised group (SG) or an app group (AG). Both groups were instructed to perform 4x4-min intervals with a rate of perceived exertion of 16 to 17, corresponding to 85% to 95% of the maximal heart rate, twice a week for 10 weeks. Treadmill VO(2max) and HRQoL measured using RAND-36 were assessed before and after the exercise period. RESULTS: VO(2max) increased (P<.001) in both groups after 10 weeks of HIIT, with improvements of 3.6 (SD 1.3) mL/kg/min in the SG and 3.7 (SD 1.5) mL/kg/min in the AG. This was accompanied by increases in oxygen pulse in both groups (P<.001), with no between-group differences apparent for either measure. Improvements in the HRQoL dimensions of bodily pain, vitality, and social functioning were observed for both groups (P<.001 to P=.04). Again, no between-group differences were detected. CONCLUSIONS: High-intensity 4x4-min interval training increased VO(2max) and HRQoL, contributing to patients' reduced cardiovascular disease risk, improved health and performance, and enhanced quality of life. Similar improvements were observed following HIIT when IRD patients were guided using perceived exertion by health care professionals or the training was self-administered and guided by the app Myworkout GO. Utilization of the app may help reduce the cost of HIIT as a treatment strategy in this patient population. TRIAL REGISTRATION: ClinicalTrials.gov NCT04649528; https://clinicaltrials.gov/ct2/show/NCT04649528. CI - (c)Havard Haglo, Eivind Wang, Ole Kristian Berg, Jan Hoff, Jan Helgerud. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 21.10.2021. FAU - Haglo, Havard AU - Haglo H AUID- ORCID: 0000-0001-7147-4463 AD - Faculty of Health and Social Sciences, Molde University College, Molde, Norway. AD - Myworkout, Medical Rehabilitation Clinic, Trondheim, Norway. FAU - Wang, Eivind AU - Wang E AUID- ORCID: 0000-0002-6322-2159 AD - Faculty of Health and Social Sciences, Molde University College, Molde, Norway. AD - Department of Medicine, University of Utah, Salt Lake City, UT, United States. FAU - Berg, Ole Kristian AU - Berg OK AUID- ORCID: 0000-0003-1538-6156 AD - Faculty of Health and Social Sciences, Molde University College, Molde, Norway. FAU - Hoff, Jan AU - Hoff J AUID- ORCID: 0000-0002-8432-7304 AD - Myworkout, Medical Rehabilitation Clinic, Trondheim, Norway. AD - Department of Physical Medicine and Rehabilitation, St. Olav's University Hospital, Trondheim, Norway. FAU - Helgerud, Jan AU - Helgerud J AUID- ORCID: 0000-0002-7796-5594 AD - Myworkout, Medical Rehabilitation Clinic, Trondheim, Norway. AD - Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. LA - eng SI - ClinicalTrials.gov/NCT04649528 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20211021 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Exercise MH - Female MH - *High-Intensity Interval Training MH - Humans MH - Male MH - Middle Aged MH - Quality of Life MH - *Rheumatic Diseases/therapy MH - Smartphone PMC - PMC8569541 OTO - NOTNLM OT - VO2max OT - cardiovascular health OT - endurance training OT - maximal oxygen uptake OT - mobile app OT - quality of life COIS- Conflicts of Interest: HH is employed by Myworkout, Medical Rehabilitation Clinic owned by Myworkout AS, the developer of the smartphone app Myworkout GO. J Helgerud and J Hoff are board members and shareholders of Myworkout AS. Due to the potential conflict of interest, EW and OKB monitored adherence to the design and statistical analysis in the study. There are no further disclosures or potential conflicts of interest to report. EDAT- 2021/10/22 06:00 MHDA- 2021/11/03 06:00 PMCR- 2021/10/21 CRDT- 2021/10/21 21:08 PHST- 2021/02/22 00:00 [received] PHST- 2021/06/25 00:00 [accepted] PHST- 2021/05/27 00:00 [revised] PHST- 2021/10/21 21:08 [entrez] PHST- 2021/10/22 06:00 [pubmed] PHST- 2021/11/03 06:00 [medline] PHST- 2021/10/21 00:00 [pmc-release] AID - v9i10e28124 [pii] AID - 10.2196/28124 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2021 Oct 21;9(10):e28124. doi: 10.2196/28124.