PMID- 34674554
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20211122
IS  - 1941-7632 (Electronic)
IS  - 1941-7640 (Linking)
VI  - 14
IP  - 11
DP  - 2021 Nov
TI  - Association Between Stent Implantation and Progression of Nontarget Lesions in a 
      Rabbit Model of Atherosclerosis.
PG  - e010764
LID - 10.1161/CIRCINTERVENTIONS.121.010764 [doi]
AB  - BACKGROUND: Progression of nontarget lesions (NTLs) after percutaneous coronary 
      intervention (PCI) has been reported. However, it remains unknown whether 
      progression of NTLs was causally related to stenting. This study was undertaken 
      to test the hypothesis that stent implantation triggers acute phase response and 
      systemic inflammation which may be associated with progression of NTLs. METHODS: 
      Thirty New Zealand rabbits receiving endothelial denudation and atherogenic diet 
      were randomly divided into stenting, sham, and control groups. Angiography and 
      intravascular ultrasonography were performed in the stenting and sham groups, and 
      stent implantation performed only in the stenting group. Histopathologic study 
      was conducted and serum levels of APPs (acute phase proteins) measured in all 
      rabbits. Proteomics analysis was performed to screen the potential proteins 
      related to NTLs progression after stent implantation. The serum levels of APPs 
      and inflammatory cytokines were measured in 147 patients undergoing coronary 
      angiography or PCI. RESULTS: Plaque burden in the NTLs was significantly 
      increased 12 weeks after stent implantation in the stenting group versus sham 
      group. Serum levels of APPs and their protein expression in NTLs were 
      significantly increased and responsible for stenting-triggered inflammation. In 
      patients receiving PCI, serum levels of SAA-1 (serum amyloid A protein 1), CRP 
      (C-reactive protein), TNF (tumor necrosis factor)-alpha, and IL (interleukin)-6 were 
      substantially elevated up to 1 month post-PCI. CONCLUSIONS: In a rabbit model of 
      atherosclerosis, stent implantation triggered acute phase response and systemic 
      inflammation, which was associated with increased plaque burden and pathological 
      features of unstable plaque in NTLs. The potential mechanism involved vessel 
      injury-triggered acute phase response manifested as increased serum levels of 
      SAA-1, CRP, and LBP (lipopolysaccharide-binding protein) and their protein 
      expression in NTLs. These findings provided a new insight into the relation 
      between stent implantation and progression of NTLs, and further studies are 
      warranted to clarify the detailed mechanism and clinical significance of these 
      preliminary results. Registration: URL: http://www.chictr.org.cn; Unique 
      identifier: ChiCTR1900026393. Graphic Abstract: A graphic abstract is available 
      for this article.
FAU - Ma, Jing
AU  - Ma J
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Liu, Xiaoling
AU  - Liu X
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Qiao, Lei
AU  - Qiao L
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Meng, Linlin
AU  - Meng L
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Xu, Xingli
AU  - Xu X
AUID- ORCID: 0000-0002-7188-5614
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Xue, Fei
AU  - Xue F
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Cheng, Cheng
AU  - Cheng C
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Han, Ziqi
AU  - Han Z
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Lu, Yue
AU  - Lu Y
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Zhang, Wencheng
AU  - Zhang W
AUID- ORCID: 0000-0002-9416-6540
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Bu, Peili
AU  - Bu P
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Zhang, Meng
AU  - Zhang M
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - An, Guipeng
AU  - An G
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Lu, Huixia
AU  - Lu H
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Ni, Mei
AU  - Ni M
AUID- ORCID: 0000-0002-8502-3337
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Zhang, Cheng
AU  - Zhang C
AUID- ORCID: 0000-0003-3672-6543
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
FAU - Zhang, Yun
AU  - Zhang Y
AUID- ORCID: 0000-0003-4432-6144
AD  - The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education, Chinese National Health Commission and Chinese Academy of 
      Medical Sciences, The State and Shandong Province Joint Key Laboratory of 
      Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211022
PL  - United States
TA  - Circ Cardiovasc Interv
JT  - Circulation. Cardiovascular interventions
JID - 101499602
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Animals
MH  - *Atherosclerosis/diagnostic imaging/etiology
MH  - C-Reactive Protein
MH  - Coronary Angiography
MH  - Humans
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Rabbits
MH  - Stents
OTO - NOTNLM
OT  - acute coronary syndrome
OT  - atherosclerosis
OT  - inflammation
OT  - percutaneous coronary intervention
EDAT- 2021/10/23 06:00
MHDA- 2021/11/23 06:00
CRDT- 2021/10/22 05:26
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2021/10/22 05:26 [entrez]
AID - 10.1161/CIRCINTERVENTIONS.121.010764 [doi]
PST - ppublish
SO  - Circ Cardiovasc Interv. 2021 Nov;14(11):e010764. doi: 
      10.1161/CIRCINTERVENTIONS.121.010764. Epub 2021 Oct 22.