PMID- 34674867 OWN - NLM STAT- MEDLINE DCOM- 20211101 LR - 20211101 IS - 1876-7605 (Electronic) IS - 1936-8798 (Linking) VI - 14 IP - 20 DP - 2021 Oct 25 TI - Clinical Outcomes Following Isolated Transcatheter Tricuspid Valve Repair: A Meta-Analysis and Meta-Regression Study. PG - 2285-2295 LID - S1936-8798(21)01590-9 [pii] LID - 10.1016/j.jcin.2021.08.050 [doi] AB - OBJECTIVES: The aim of this study was to assess the pooled clinical and echocardiographic outcomes of different isolated transcatheter tricuspid valve repair (ITTVR) strategies for significant (moderate or greater) tricuspid regurgitation (TR). BACKGROUND: Significant TR is a common valvular heart disease worldwide. METHODS: Published research was systematically searched for studies evaluating the efficacy and safety of ITTVR for significant TR in adults. The primary outcomes were improvement in New York Heart Association (NYHA) functional class and 6-minute walking distance and the presence of severe or greater TR at the last available follow-up of each individual study. Random-effect meta-analysis was performed comparing outcomes before and after ITTVR. RESULTS: Fourteen studies with 771 patients were included. The mean age was 77 +/- 8 years, and the mean European System for Cardiac Operative Risk Evaluation II score was 6.8% +/- 5.4%. At a weighted mean follow-up of 212 days, 209 patients (35%) were in NYHA functional class III or IV compared with 586 patients (84%) at baseline (risk ratio: 0.23; 95% CI: 0.13-0.40; P < 0.001). Six-minute walking distance significantly improved from 237 +/- 113 m to 294 +/- 105 m (mean difference +50 m; 95% CI: +34 to +66 m; P < 0.001). One hundred forty-seven patients (24%) showed severe or greater TR after ITTVR compared with 616 (96%) at baseline (risk ratio: 0.29; 95% CI: 0.20-0.42; P < 0.001). CONCLUSIONS: Patients undergoing ITTVR for significant TR experienced significant improvements in NYHA functional status and 6-minute walking distance and a significant reduction in TR severity at mid-term follow-up. CI - Copyright (c) 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Bocchino, Pier Paolo AU - Bocchino PP AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. Electronic address: pierpaolo1991@gmail.com. FAU - Angelini, Filippo AU - Angelini F AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Vairo, Alessandro AU - Vairo A AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Andreis, Alessandro AU - Andreis A AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Fortuni, Federico AU - Fortuni F AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. FAU - Franchin, Luca AU - Franchin L AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Frea, Simone AU - Frea S AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Raineri, Claudia AU - Raineri C AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Pidello, Stefano AU - Pidello S AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Conrotto, Federico AU - Conrotto F AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Montefusco, Antonio AU - Montefusco A AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - Alunni, Gianluca AU - Alunni G AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. FAU - De Ferrari, Gaetano Maria AU - De Ferrari GM AD - Division of Cardiology, Department of Medical Sciences, University of Turin, "Citta della Salute e della Scienza" Hospital, Turin, Italy. LA - eng PT - Journal Article PT - Meta-Analysis PL - United States TA - JACC Cardiovasc Interv JT - JACC. Cardiovascular interventions JID - 101467004 SB - IM CIN - JACC Cardiovasc Interv. 2021 Oct 25;14(20):2296-2297. PMID: 34674868 MH - Aged MH - Aged, 80 and over MH - Cardiac Catheterization/adverse effects MH - *Heart Valve Prosthesis Implantation/adverse effects MH - Humans MH - Severity of Illness Index MH - Time Factors MH - Treatment Outcome MH - Tricuspid Valve/diagnostic imaging/surgery MH - *Tricuspid Valve Insufficiency/diagnostic imaging/surgery OTO - NOTNLM OT - TTVR OT - transcatheter intervention OT - transcatheter tricuspid valve repair OT - tricuspid regurgitation OT - tricuspid valve COIS- Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose. EDAT- 2021/10/23 06:00 MHDA- 2021/11/03 06:00 CRDT- 2021/10/22 05:41 PHST- 2021/05/13 00:00 [received] PHST- 2021/07/06 00:00 [revised] PHST- 2021/08/10 00:00 [accepted] PHST- 2021/10/22 05:41 [entrez] PHST- 2021/10/23 06:00 [pubmed] PHST- 2021/11/03 06:00 [medline] AID - S1936-8798(21)01590-9 [pii] AID - 10.1016/j.jcin.2021.08.050 [doi] PST - ppublish SO - JACC Cardiovasc Interv. 2021 Oct 25;14(20):2285-2295. doi: 10.1016/j.jcin.2021.08.050.