PMID- 34675479
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 15
DP  - 2021
TI  - Intra-Operative Discomfort in Photorefractive Keratectomy.
PG  - 4121-4130
LID - 10.2147/OPTH.S327057 [doi]
AB  - PURPOSE: Photorefractive keratectomy (PRK) remains a viable, safe, and 
      efficacious option for patients wishing to correct refractive errors. One of its 
      most significant drawbacks is pain. While post-operative pain has been well 
      studied with different management options, intra-operative pain has been less 
      well defined. The purpose of this study was to characterize intra-operative pain 
      during PRK in regard to eye operated on, gender, excimer platform used, surgeon, 
      and age. PATIENTS AND METHODS: A total of 134 patients (264 eyes) were 
      prospectively randomized to undergo bilateral PRK of either the right eye first 
      or the left eye first followed immediately by the fellow eye. In the immediate 
      post-operative period they were surveyed using an 11-point Numeric Rating Scale 
      regarding intra-operative pain or discomfort experienced in each eye. Resultant 
      pain scores were then analyzed via two sample z-test and analysis of variance 
      (ANOVA) to characterize pain overall as well as comparing first versus second eye 
      operated on, right versus left eye, male versus female, excimer platform used, 
      inter-surgeon variability, and age. RESULTS: Of 264 eyes surveyed the mean pain 
      experienced on a 0-10 pain scale was 1.13 (minimal discomfort). There was no 
      statistically significant difference in pain or discomfort when comparing first 
      versus second eye operated on, right versus left eye, male versus female, excimer 
      platform used, operating surgeon, or age. CONCLUSION: Intra-operative pain or 
      discomfort experienced by patients is minimal. The absence of statistically 
      significant differences in pain scores studied implies that standard of care 
      procedures achieve adequate analgesia in PRK.
CI  - (c) 2021 Philbrick and Bennion.
FAU - Philbrick, Samuel M
AU  - Philbrick SM
AD  - Department of Operational and Readiness Medicine, Joint Base Elmendorf-Richardson 
      Hospital, Elmendorf, AK, USA.
FAU - Bennion, John L
AU  - Bennion JL
AUID- ORCID: 0000-0002-9243-1187
AD  - Department of Ophthalmology, Saint Alphonsus Health System, Boise, ID, USA.
LA  - eng
PT  - Journal Article
DEP - 20211013
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC8520965
OTO - NOTNLM
OT  - CRS
OT  - EX500
OT  - LASEK
OT  - LASIK
OT  - PRK
OT  - VISX
OT  - analgesia
OT  - anesthetic
OT  - corneal refractive surgery
OT  - inter-surgeon variability
OT  - laser assisted sub-epithelial keratectomy
OT  - laser in situ keratomileusis
OT  - military medicine
OT  - myopia
OT  - order effect
OT  - pain
OT  - z-test
COIS- The authors have no conflicts of interest to disclose relating to this work.
EDAT- 2021/10/23 06:00
MHDA- 2021/10/23 06:01
PMCR- 2021/10/13
CRDT- 2021/10/22 06:44
PHST- 2021/07/03 00:00 [received]
PHST- 2021/09/09 00:00 [accepted]
PHST- 2021/10/22 06:44 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/10/23 06:01 [medline]
PHST- 2021/10/13 00:00 [pmc-release]
AID - 327057 [pii]
AID - 10.2147/OPTH.S327057 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2021 Oct 13;15:4121-4130. doi: 10.2147/OPTH.S327057. eCollection 
      2021.