PMID- 34675729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211023
IS  - 1179-1608 (Print)
IS  - 1179-1608 (Electronic)
IS  - 1179-1608 (Linking)
VI  - 13
DP  - 2021
TI  - Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in 
      Perimenopause.
PG  - 1823-1863
LID - 10.2147/NSS.S332474 [doi]
AB  - Comorbid depression and insomnia are ubiquitous mental complaints among women 
      going through the perimenopausal stage of life and can result in major decline in 
      quality of life. Antidepressive agents combined with/without hypnotics, and/or 
      hormone therapy are currently the most common treatment for perimenopausal 
      depression (PMD) and insomnia (PMI). Balancing the benefits of these 
      pharmacotherapies against the risk of adverse events (AEs) is a difficult task 
      for both clinicians and women. There has been a growing body of research 
      regarding the utilization of acupuncture for treatment of PMD or PMI, whereas no 
      studies of acupuncture for comorbid PMD and PMI have appeared. In this review, we 
      summarize the clinical and preclinical evidence of acupuncture as a treatment for 
      PMD or PMI, and then discuss the potential mechanisms involved and the role of 
      acupuncture in helping women during this transition. Most clinical trials 
      indicate that acupuncture ameliorates not only PMD/PMI but also climacteric 
      symptoms with minimal AEs. It also regulates serum hormone levels. The 
      reliability of trials is however limited due to methodological flaws in most 
      studies. Rodent studies suggest that acupuncture prolongs total sleep time and 
      reduces depression-like behavior in PMI and PMD models, respectively. These 
      effects are possibly mediated through multiple mechanisms of action, including 
      modulating sex hormones, neurotransmitters, hypothalamic-pituitary-adrenal 
      axis/hypothalamic-pituitary-ovary axis, oxidative stress, signaling pathways, and 
      other cellular events. In conclusion, acupuncture is a promising therapeutic 
      strategy for comorbid depression and insomnia during perimenopause. 
      Neuroendocrine modulation is likely to play a major role in mediating those 
      effects. High-quality trials are required to further validate acupuncture's 
      effectiveness.
CI  - (c) 2021 Zhao et al.
FAU - Zhao, Fei-Yi
AU  - Zhao FY
AUID- ORCID: 0000-0001-9009-8870
AD  - School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 
      3083, Australia.
AD  - Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University 
      of Traditional Chinese Medicine, Shanghai, 200071, People's Republic of China.
AD  - Department of Nursing, School of International Medical Technology, Shanghai Sanda 
      University, Shanghai, 201209, People's Republic of China.
FAU - Fu, Qiang-Qiang
AU  - Fu QQ
AUID- ORCID: 0000-0002-2369-1508
AD  - Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, 
      People's Republic of China.
FAU - Spencer, Sarah J
AU  - Spencer SJ
AUID- ORCID: 0000-0001-8832-4824
AD  - School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 
      3083, Australia.
AD  - ARC Centre of Excellence for Nanoscale Biophotonics, RMIT University, Bundoora, 
      Victoria, 3083, Australia.
FAU - Kennedy, Gerard A
AU  - Kennedy GA
AUID- ORCID: 0000-0002-4419-050X
AD  - School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 
      3083, Australia.
AD  - School of Science, Psychology and Sport, Federation University, Mount Helen, 
      Victoria, Australia.
AD  - Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, 3084, 
      Australia.
FAU - Conduit, Russell
AU  - Conduit R
AUID- ORCID: 0000-0001-9356-6844
AD  - School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 
      3083, Australia.
FAU - Zhang, Wen-Jing
AU  - Zhang WJ
AUID- ORCID: 0000-0002-3716-6800
AD  - Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University 
      of Traditional Chinese Medicine, Shanghai, 200071, People's Republic of China.
FAU - Zheng, Zhen
AU  - Zheng Z
AUID- ORCID: 0000-0001-6777-1166
AD  - School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 
      3083, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211012
PL  - New Zealand
TA  - Nat Sci Sleep
JT  - Nature and science of sleep
JID - 101537767
PMC - PMC8520448
OTO - NOTNLM
OT  - acupuncture
OT  - comorbid
OT  - depression
OT  - insomnia
OT  - mechanisms
OT  - perimenopause
COIS- None of the authors have any conflicts of interest to declare in this study.
EDAT- 2021/10/23 06:00
MHDA- 2021/10/23 06:01
PMCR- 2021/10/12
CRDT- 2021/10/22 06:46
PHST- 2021/08/03 00:00 [received]
PHST- 2021/09/24 00:00 [accepted]
PHST- 2021/10/22 06:46 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/10/23 06:01 [medline]
PHST- 2021/10/12 00:00 [pmc-release]
AID - 332474 [pii]
AID - 10.2147/NSS.S332474 [doi]
PST - epublish
SO  - Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 
      2021.