PMID- 34675787
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211023
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 15
DP  - 2021
TI  - Functional Integration of Adult-Generated Neurons in Diabetic Goto-Kakizaki Rats.
PG  - 734359
LID - 10.3389/fnbeh.2021.734359 [doi]
LID - 734359
AB  - Adult-born neurons in the dentate gyrus (DG) make important contributions to 
      learning as they integrate into neuronal networks. Neurogenesis is dramatically 
      reduced by a number of conditions associated with cognitive impairment, including 
      type 2 diabetes mellitus (T2DM). Increasing neurogenesis may thus provide a 
      therapeutic target for ameliorating diabetes-associated cognitive impairments, 
      but only if new neurons remain capable of normal function. To address the 
      capacity for adult-generated neurons to incorporate into functional circuits in 
      the hyperglycemic DG, we measured Egr1 expression in granule cells (GCs), BrdU 
      labeled four weeks prior, in Goto-Kakizaki (GK) rats, an established model of 
      T2DM, and age-matched Wistars. The results indicate that while fewer GCs are 
      generated in the DG of GK rats, GCs that survive readily express Egr1 in response 
      to spatial information. These data demonstrate that adult-generated GCs in the 
      hyperglycemic DG remain functionally competent and support neurogenesis as a 
      viable therapeutic target.
CI  - Copyright (c) 2021 Damphousse, Medeiros and Marrone.
FAU - Damphousse, Chelsey C
AU  - Damphousse CC
AD  - Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.
FAU - Medeiros, Jaclyn
AU  - Medeiros J
AD  - Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.
FAU - Marrone, Diano F
AU  - Marrone DF
AD  - Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20211005
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC8523851
OTO - NOTNLM
OT  - IEG expression
OT  - dentate gyrus
OT  - diabetes
OT  - neurogenesis
OT  - spatial cognition
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/23 06:00
MHDA- 2021/10/23 06:01
PMCR- 2021/01/01
CRDT- 2021/10/22 06:47
PHST- 2021/07/01 00:00 [received]
PHST- 2021/08/31 00:00 [accepted]
PHST- 2021/10/22 06:47 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/10/23 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2021.734359 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2021 Oct 5;15:734359. doi: 10.3389/fnbeh.2021.734359. 
      eCollection 2021.