PMID- 34675798
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211023
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Textual Inference Comprehension in Mild Cognitive Impairment: The Influence of 
      Semantic Processing and Verbal Episodic Memory.
PG  - 735633
LID - 10.3389/fnagi.2021.735633 [doi]
LID - 735633
AB  - Language complaints, especially in complex tasks, may occur in mild cognitive 
      impairment (MCI). Various language measures have been studied as cognitive 
      predictors of MCI conversion to Alzheimer's type dementia. Understanding textual 
      inferences is considered a high-demanding task that recruits multiple cognitive 
      functions and, therefore, could be sensitive to detect decline in the early 
      stages of MCI. Thus, we aimed to compare the performance of subjects with MCI to 
      healthy elderly in a textual inference comprehension task and to determine the 
      best predictors of performance in this ability considering one verbal episodic 
      memory and two semantic tasks. We studied 99 individuals divided into three 
      groups: (1) 23 individuals with amnestic mild cognitive impairment (aMCI), (2) 42 
      individuals with non-amnestic mild cognitive impairment (naMCI), (3), and (4) 34 
      cognitively healthy individuals for the control group (CG). A reduced version of 
      The Implicit Management Test was used to assess different types of inferential 
      reasoning in text reading. MCI patients performed poorer than healthy elderly, 
      and there were no differences between MCI subgroups (amnestic and non-amnestic). 
      The best predictors for inference-making were verbal memory in the aMCI and 
      semantic tasks in the naMCI group. The results confirmed that the failure to 
      understand textual inferences can be present in MCI and showed that different 
      cognitive skills like semantic knowledge and verbal episodic memory are necessary 
      for inference-making.
CI  - Copyright (c) 2021 Maziero, Belan, Camargo, Silagi, Forlenza and Radanovic.
FAU - Maziero, Maria Paula
AU  - Maziero MP
AD  - Department of Psychiatry, School of Medicine, University of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Belan, Ariella Fornachari Ribeiro
AU  - Belan AFR
AD  - Department of Psychiatry, School of Medicine, University of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Camargo, Marina von Zuben de Arruda
AU  - Camargo MVZA
AD  - Department of Psychiatry, School of Medicine, University of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Silagi, Marcela Lima
AU  - Silagi ML
AD  - Department of Speech, Language and Hearing Sciences, Federal University of Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Forlenza, Orestes Vicente
AU  - Forlenza OV
AD  - Department of Psychiatry, School of Medicine, University of Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Radanovic, Marcia
AU  - Radanovic M
AD  - Department of Psychiatry, School of Medicine, University of Sao Paulo, Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20211004
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8524675
OTO - NOTNLM
OT  - comprehension
OT  - inference
OT  - mild cognitive impairment (MCI)
OT  - semantic processing
OT  - text
OT  - verbal episodic memory
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/23 06:00
MHDA- 2021/10/23 06:01
PMCR- 2021/01/01
CRDT- 2021/10/22 06:47
PHST- 2021/07/03 00:00 [received]
PHST- 2021/09/03 00:00 [accepted]
PHST- 2021/10/22 06:47 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/10/23 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.735633 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Oct 4;13:735633. doi: 10.3389/fnagi.2021.735633. 
      eCollection 2021.