PMID- 34675887
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20220215
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 
      Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids.
PG  - 754006
LID - 10.3389/fendo.2021.754006 [doi]
LID - 754006
AB  - BACKGROUND: As metabolic molecules, bile acids (BAs) not only promote the 
      absorption of fat-soluble nutrients, but they also regulate many metabolic 
      processes, including the homeostasis of glucose and lipids. Although total serum 
      BA (TBA) measurement is a readily available clinical test related to coronary 
      artery disease (CAD), myocardial infarction (MI), and type 2 diabetes mellitus 
      (T2DM), the relationship between TBA and these pathological conditions remain 
      unclear, and research on this topic is inconclusive. METHODS: This study enrolled 
      20,255 menopausal women aged over 50 years, including 6,421 T2DM patients. The 
      study population was divided into different groups according to the median TBA 
      level in order to explore the clinical characteristics of menopausal women with 
      different TBA levels. Spline analyses, generalized additive model (GAM) model and 
      regression analyses based on TBA level were used to explore the relationship 
      between TBA and different diseases independently, including CAD and MI, or in 
      combination with T2DM. RESULTS: Both in the general population and in the T2DM 
      subgroup, the TBA level was significantly lower in CAD patients than in non-CAD 
      patients. Spline analyses indicated that within normal clinical range of TBA 
      concentration (0-10 micromol/L), the presence of CAD and MI showed similar trends in 
      total and T2DM population. Similarly, the GAM model indicated that within the 
      0-10 mumol/L clinical range, the predicted probability for CAD and MI alone and in 
      combination with T2DM was negatively correlated with TBA concentration. 
      Multivariate regression analysis suggested that low TBA level was positively 
      associated with the occurrence of CAD combined with T2DM (OR: 1.451; 95%CI: 
      1.141-1.847). CONCLUSIONS: In menopausal women, TBA may represent a valuable 
      clinical serum marker with negative correlation for CAD and MI in patients with 
      T2DM.
CI  - Copyright (c) 2021 Feng, Zhai, Yang, Liu, Zhou and Guo.
FAU - Feng, Xunxun
AU  - Feng X
AD  - Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, 
      Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for 
      Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China.
FAU - Zhai, Guangyao
AU  - Zhai G
AD  - Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, 
      Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for 
      Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China.
FAU - Yang, Jiaqi
AU  - Yang J
AD  - Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, 
      Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for 
      Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, 
      Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for 
      Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China.
FAU - Zhou, Yujie
AU  - Zhou Y
AD  - Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, 
      Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for 
      Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China.
FAU - Guo, Qianyun
AU  - Guo Q
AD  - Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, 
      Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for 
      Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, 
      Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211005
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Bile Acids and Salts)
SB  - IM
EIN - Front Endocrinol (Lausanne). 2021 Nov 23;12:799920. PMID: 34887840
MH  - Aged
MH  - Bile Acids and Salts/*blood
MH  - Coronary Artery Disease/*blood
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Humans
MH  - Menopause/*blood
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
MH  - Retrospective Studies
PMC - PMC8524089
OTO - NOTNLM
OT  - coronary artery disease
OT  - menopausal women
OT  - myocardial infarction
OT  - total serum bile acids
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/23 06:00
MHDA- 2022/02/16 06:00
PMCR- 2021/01/01
CRDT- 2021/10/22 06:48
PHST- 2021/08/05 00:00 [received]
PHST- 2021/09/14 00:00 [accepted]
PHST- 2021/10/22 06:48 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.754006 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 Oct 5;12:754006. doi: 
      10.3389/fendo.2021.754006. eCollection 2021.