PMID- 3467658
OWN - NLM
STAT- MEDLINE
DCOM- 19870203
LR  - 20201214
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 123
IP  - 1
DP  - 1987 Jan
TI  - Subacute cutaneous lupus erythematosus in multiple members of a family with C2 
      deficiency.
PG  - 66-70
AB  - Deficiency of the second component of complement (C2d) has been associated with 
      systemic lupus erythematosus (LE)-like syndromes as well as recurrent infections. 
      In particular, C2d has been associated with the LE subset of subacute cutaneous 
      LE (SCLE), the presence of anti-Ro antibodies (anti-Ro or SS-A), and the human 
      leukocyte antigen (HLA) types A25, B18, and DR2. A family with C2d in which three 
      members have developed SCLE was observed and studied clinically, serologically, 
      and immunogenetically. Deficiency of the second component of complement was 
      present in all six family members, while anti-Ro was present in only two. There 
      was a strong but incomplete association of C2d and SCLE with HLA-DR2, but the 
      association was not complete with positivity of anti-Ro or antinuclear 
      antibodies. Study of this family reconfirmed the close association of HLA-A25, 
      -B18 and -DR2 with the C2 gene, but indicated a less close association of these 
      loci with serologic markers.
FAU - Callen, J P
AU  - Callen JP
FAU - Hodge, S J
AU  - Hodge SJ
FAU - Kulick, K B
AU  - Kulick KB
FAU - Stelzer, G
AU  - Stelzer G
FAU - Buchino, J J
AU  - Buchino JJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Autoantigens)
RN  - 0 (Complement C2)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (RNA, Small Cytoplasmic)
RN  - 0 (RO60 protein, human)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (SS-A antigen)
SB  - IM
MH  - Adult
MH  - Autoantigens/genetics
MH  - Complement C2/*deficiency
MH  - Female
MH  - HLA Antigens/genetics
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*genetics/immunology
MH  - Male
MH  - *RNA, Small Cytoplasmic
MH  - *Ribonucleoproteins
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Arch Dermatol. 1987 Jan;123(1):66-70.