PMID- 34677019
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220915
IS  - 1872-2059 (Electronic)
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 39
IP  - 11
DP  - 2021 Nov
TI  - [Simultaneous determination of 11 volatile perfluorinated compound precursors in 
      textiles using gas chromatography-triple quadrupole mass spectrometry].
PG  - 1239-1246
LID - 10.3724/SP.J.1123.2021.01043 [doi]
AB  - Perfluorinated compounds (PFCs) are persistent organic compounds. PFCs are 
      artificially prepared hydrocarbons in which hydrogen atoms are completely 
      replaced by fluorine. PFCs have excellent thermal stability and chemical 
      stability, high surface activity, and hydrophobic and/or oleophobic properties 
      owing to their exceptionally strong C-F bonds, low polarizability, and weak 
      intermolecular van der Waals interactions. Currently, PFCs and their precursors 
      are widely used in textile production as finishing agents and surfactants. In 
      recent years, increasing attention has been devoted to PFCs and their precursors. 
      In many countries and regions, such as the European Union, Canada, Denmark, and 
      the United States, directives and regulations have been issued to restrict the 
      use of PFCs and their precursors; the number of these compounds in such lists is 
      increasing continuously. Studies have shown that PFCs are hepatotoxic, 
      embryotoxic, reproductive-toxic, neurotoxic, and carcinogenic, and can interfere 
      with the endocrine system, change animal instinct behavior, and potentially 
      induce developmental neurotoxicity in humans, especially in young children. 
      However, there are few established methods for the simultaneous detection of 
      multiple PFC precursors, necessitating the same particularly for textiles. In 
      this study, a method was developed for the simultaneous determination of 11 
      volatile PFC precursors in textiles using gas chromatography-triple quadrupole 
      tandem mass spectrometry (GC-MS/MS). The target compounds included four 
      fluorotelomer alcohols (FTOHs), three fluorotelomer acrylates (FTAs), two 
      fluorooctane sulfonamides (FOSAs), and two fluorooctane sulfonamide-ethanols 
      (FOSEs). Studies have shown that FTOHs and FTAs are precursors of 
      perfluorocarboxylic acid, and FOSAs are precursors of perfluorooctanesulfonic 
      acid. Some PFC precursors are converted into perfluorocarboxylic acid and 
      perfluoroalkyl sulfonic acid, which threaten human health and ecological 
      security. In this study, an effective ultrasonic-assisted extraction method for 
      the 11 target compounds was established. The effects of the extraction solvent, 
      extraction temperature, and extraction time on the extraction efficiency were 
      investigated. The optimum extraction conditions for the developed method were 
      carrying out ultrasonic extraction at 70 ℃ for 60 min with methanol as the 
      extraction solvent. Separation was performed on a VF-WAXms capillary column (30 
      mx0.25 mmx0.25 mum) with temperature programming, following which the target 
      compounds were detected by GC-MS/MS in the multiple reaction monitoring (MRM) 
      mode and quantified using the external standard method. The matrix effects of 
      three textile matrices were also investigated. The calibration curves of the 11 
      volatile PFC precursors showed good linearity in the concentration range of 
      10-500 mug/L with correlation coefficients not less than 0.9984. The limits of 
      detection were 0.002-0.04 mg/kg (S/N=3), and limits of quantification were 
      0.006-0.1 mg/kg (S/N=10). The recoveries for the 11 analytes in different textile 
      matrix samples at three spiked levels ranged from 73.2% to 117.2% with relative 
      standard deviations (RSDs) of 0.1%-9.4% (n=6). Through actual sample analysis, 
      four PFC precursors were detected in the textile product samples. The method has 
      the advantages of simple pretreatment, accurate qualitative and quantitative 
      analysis, high sensitivity, and good reproducibility. It can be effectively used 
      for the simultaneous determination of 11 volatile PFC precursors in textiles. The 
      establishment of this method has theoretical and practical significance for 
      controlling PFC precursor levels in textiles. This study offers a new testing 
      method for mitigating risk to safety and controlling textile products. It also 
      provides a reference for establishing testing standards for PFC precursors in 
      textiles and other similar consumer goods.
FAU - Wang, Chunlan
AU  - Wang C
AD  - Shenzhen Academy of Metrology and Quality Inspection, Shenzhen 518109, China.
FAU - Zhang, Haixuan
AU  - Zhang H
AD  - Shenzhen Academy of Metrology and Quality Inspection, Shenzhen 518109, China.
FAU - Zhu, Li
AU  - Zhu L
AD  - Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
FAU - Hu, Wangxia
AU  - Hu W
AD  - Shenzhen Academy of Metrology and Quality Inspection, Shenzhen 518109, China.
FAU - Lin, Ziwei
AU  - Lin Z
AD  - Shenzhen Academy of Metrology and Quality Inspection, Shenzhen 518109, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Solvents)
SB  - IM
MH  - Animals
MH  - Child, Preschool
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Reproducibility of Results
MH  - Solvents
MH  - *Tandem Mass Spectrometry
MH  - *Textiles
PMC - PMC9404008
OTO - NOTNLM
OT  - gas chromatography-tandem mass spectrometry (GC-MS/MS)
OT  - perfluorinated compound precursors
OT  - textiles
EDAT- 2021/10/23 06:00
MHDA- 2021/10/26 06:00
PMCR- 2021/11/08
CRDT- 2021/10/22 08:57
PHST- 2021/10/22 08:57 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/11/08 00:00 [pmc-release]
AID - 1000-8713-39-11-1239 [pii]
AID - 10.3724/SP.J.1123.2021.01043 [doi]
PST - ppublish
SO  - Se Pu. 2021 Nov;39(11):1239-1246. doi: 10.3724/SP.J.1123.2021.01043.