PMID- 34677372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230802
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Sep 28
TI  - In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels.
LID - 10.3390/metabo11100657 [doi]
LID - 657
AB  - Animal studies have shown that developmental exposures to polybrominated diphenyl 
      ethers (PBDE) permanently affect blood/liver balance of lipids. No human study 
      has evaluated associations between in utero exposures to persistent organic 
      pollutants (POPs) and later life lipid metabolism. In this pilot, maternal plasma 
      levels of PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) and polychlorinated 
      biphenyls (PCB-138, PCB-153, and PCB-180) were determined at delivery in 
      participants of GESTation and Environment (GESTE) cohort. Total cholesterol 
      (TCh), triglycerides (TG), low- and high-density lipoproteins (LDL-C and HDL-C), 
      total lipids (TL), and PBDEs were determined in serum of 147 children at ages 
      6-7. General linear regression was used to estimate the relationship between 
      maternal POPs and child lipid levels with adjustment for potential confounders, 
      and adjustment for childhood POPs. In utero BDE-99 was associated with lower 
      childhood levels of TG (p = 0.003), and non-significantly with HDL-C (p = 0.06) 
      and TL (p = 0.07). Maternal PCB-138 was associated with lower childhood levels of 
      TG (p = 0.04), LDL-C (p = 0.04), and TL (p = 0.02). Our data indicate that in 
      utero exposures to POPs may be associated with long lasting decrease in 
      circulating lipids in children, suggesting increased lipid accumulation in the 
      liver, a mechanism involved in NAFLD development, consistent with previously 
      reported animal data.
FAU - Boutot, Maegan E
AU  - Boutot ME
AD  - Department of Biostatistics and Epidemiology, School of Public Health and Health 
      Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
FAU - Whitcomb, Brian W
AU  - Whitcomb BW
AD  - Department of Biostatistics and Epidemiology, School of Public Health and Health 
      Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
FAU - Abdelouahab, Nadia
AU  - Abdelouahab N
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, 
      Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada.
FAU - Baccarelli, Andrea A
AU  - Baccarelli AA
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, NY 10032, USA.
FAU - Boivin, Amelie
AU  - Boivin A
AD  - Department of Pediatrics, Faculty of Medicine and Health Sciences, Sherbrooke 
      University, Sherbrooke, QC J1H 5N4, Canada.
FAU - Caku, Artuela
AU  - Caku A
AD  - Department of Biochemistry and Functional Genomics, Faculty of Medicine and 
      Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada.
FAU - Gillet, Virginie
AU  - Gillet V
AD  - Department of Pediatrics, Faculty of Medicine and Health Sciences, Sherbrooke 
      University, Sherbrooke, QC J1H 5N4, Canada.
FAU - Martinez, Guillaume
AU  - Martinez G
AD  - Department of Chemistry, Faculty of Sciences, Sherbrooke, QC J1K 2R1, Canada.
FAU - Pasquier, Jean-Charles
AU  - Pasquier JC
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, 
      Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada.
FAU - Zhu, Jiping
AU  - Zhu J
AD  - Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 
      0K9, Canada.
FAU - Takser, Larissa
AU  - Takser L
AD  - Department of Pediatrics & Department of Psychiatry, Faculty of Medicine and 
      Health Sciences, Sherbrooke University, Sherbrooke, QC J1H 5N4, Canada.
FAU - St-Cyr, Lindsay
AU  - St-Cyr L
AD  - Department of Pediatrics, Faculty of Medicine and Health Sciences, Sherbrooke 
      University, Sherbrooke, QC J1H 5N4, Canada.
FAU - Suvorov, Alexander
AU  - Suvorov A
AUID- ORCID: 0000-0002-2757-5897
AD  - Department of Biostatistics and Epidemiology, School of Public Health and Health 
      Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
AD  - Department of Environmental Health Sciences, School of Public Health and Health 
      Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
LA  - eng
GR  - R21 ES029686/ES/NIEHS NIH HHS/United States
GR  - R21 ES029686-01A1/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20210928
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC8540619
OTO - NOTNLM
OT  - NAFLD
OT  - dyslipidemia
OT  - fetal programing
OT  - lipid metabolism
OT  - persistent organic pollutants
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/23 06:00
MHDA- 2021/10/23 06:01
PMCR- 2021/09/28
CRDT- 2021/10/22 12:18
PHST- 2021/09/03 00:00 [received]
PHST- 2021/09/21 00:00 [revised]
PHST- 2021/09/24 00:00 [accepted]
PHST- 2021/10/22 12:18 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/10/23 06:01 [medline]
PHST- 2021/09/28 00:00 [pmc-release]
AID - metabo11100657 [pii]
AID - metabolites-11-00657 [pii]
AID - 10.3390/metabo11100657 [doi]
PST - epublish
SO  - Metabolites. 2021 Sep 28;11(10):657. doi: 10.3390/metabo11100657.