PMID- 34678951
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 9
IP  - 10
DP  - 2021 Oct 8
TI  - Type 2 Diabetes Mellitus Mediation by the Disruptive Activity of Environmental 
      Toxicants on Sex Hormone Receptors: In Silico Evaluation.
LID - 10.3390/toxics9100255 [doi]
LID - 255
AB  - This study investigates the disruptive activity of environmental toxicants on sex 
      hormone receptors mediating type 2 diabetes mellitus (T2DM). Toxicokinetics, gene 
      target prediction, molecular docking, molecular dynamics, and gene network 
      analysis were applied in silico techniques. From the results, permethrin, 
      perfluorooctanoic acid, dichlorodiphenyltrichloroethane, O-phenylphenol, 
      bisphenol A, and diethylstilbestrol were the active toxic compounds that could 
      modulate androgen (AR) and estrogen-alpha and -beta receptors (ER) to induce T2DM. Early 
      growth response 1 (EGR1), estrogen receptor 1 (ESR1), and tumour protein 63 
      (TP63) were the major transcription factors, while mitogen-activated protein 
      kinases (MAPK) and cyclin-dependent kinases (CDK) were the major kinases 
      upregulated by these toxicants via interactions with intermediary proteins such 
      as PTEN, AKT1, NfKbeta1, SMAD3 and others in the gene network analysis to mediate 
      T2DM. These toxicants pose a major challenge to public health; hence, monitoring 
      their manufacture, use, and disposal should be enforced. This would ensure 
      reduced interaction between people and these toxic chemicals, thereby reducing 
      the incidence and prevalence of T2DM.
FAU - Iheagwam, Franklyn Nonso
AU  - Iheagwam FN
AUID- ORCID: 0000-0001-8487-4052
AD  - Department of Biochemistry and Covenant University Public Health and Wellness 
      Research Cluster (CUPHWERC), Covenant University, Ota PMB 1023, Nigeria.
FAU - Odiba, Joseph Kelechi
AU  - Odiba JK
AD  - Aafud Industry Nigeria Co., Ltd., Lagos 100212, Nigeria.
FAU - Iheagwam, Olawumi Toyin
AU  - Iheagwam OT
AD  - Beloxxi Industries Ltd., Agbara 112102, Nigeria.
FAU - Ogunlana, Olubanke Olujoke
AU  - Ogunlana OO
AUID- ORCID: 0000-0001-5781-592X
AD  - Department of Biochemistry and Covenant University Public Health and Wellness 
      Research Cluster (CUPHWERC), Covenant University, Ota PMB 1023, Nigeria.
FAU - Chinedu, Shalom Nwodo
AU  - Chinedu SN
AUID- ORCID: 0000-0001-6421-2043
AD  - Department of Biochemistry and Covenant University Public Health and Wellness 
      Research Cluster (CUPHWERC), Covenant University, Ota PMB 1023, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20211008
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC8538912
OTO - NOTNLM
OT  - disruptive activity
OT  - environmental toxicants
OT  - gene network analysis
OT  - in silico
OT  - molecular docking
OT  - molecular dynamics
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/23 06:00
MHDA- 2021/10/23 06:01
PMCR- 2021/10/08
CRDT- 2021/10/22 21:02
PHST- 2021/02/11 00:00 [received]
PHST- 2021/05/09 00:00 [revised]
PHST- 2021/05/11 00:00 [accepted]
PHST- 2021/10/22 21:02 [entrez]
PHST- 2021/10/23 06:00 [pubmed]
PHST- 2021/10/23 06:01 [medline]
PHST- 2021/10/08 00:00 [pmc-release]
AID - toxics9100255 [pii]
AID - toxics-09-00255 [pii]
AID - 10.3390/toxics9100255 [doi]
PST - epublish
SO  - Toxics. 2021 Oct 8;9(10):255. doi: 10.3390/toxics9100255.