PMID- 34679421
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Oct 15
TI  - Functional Connectivity at Rest between the Human Medial Posterior Parietal 
      Cortex and the Primary Motor Cortex Detected by Paired-Pulse Transcranial 
      Magnetic Stimulation.
LID - 10.3390/brainsci11101357 [doi]
LID - 1357
AB  - The medial posterior parietal cortex (PPC) is involved in the complex processes 
      of visuomotor integration. Its connections to the dorsal premotor cortex, which 
      in turn is connected to the primary motor cortex (M1), complete the 
      fronto-parietal network that supports important cognitive functions in the 
      planning and execution of goal-oriented movements. In this study, we wanted to 
      investigate the time-course of the functional connectivity at rest between the 
      medial PPC and the M1 using dual-site transcranial magnetic stimulation in 
      healthy humans. We stimulated the left M1 using a suprathreshold test stimulus to 
      elicit motor-evoked potentials in the hand, and a subthreshold conditioning 
      stimulus was applied over the left medial PPC at different inter-stimulus 
      intervals (ISIs). The conditioning stimulus affected the M1 excitability 
      depending on the ISI, with inhibition at longer ISIs (12 and 15 ms). We suggest 
      that these modulations may reflect the activation of different parieto-frontal 
      pathways, with long latency inhibitions likely recruiting polisynaptic pathways, 
      presumably through anterolateral PPC.
FAU - Breveglieri, Rossella
AU  - Breveglieri R
AUID- ORCID: 0000-0001-5059-1441
AD  - Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 
      Bologna, Italy.
FAU - Borgomaneri, Sara
AU  - Borgomaneri S
AUID- ORCID: 0000-0003-4959-6442
AD  - Center for Studies and Research in Cognitive Neuroscience, University of Bologna, 
      47521 Cesena, Italy.
AD  - IRCCS Santa Lucia Foundation, 00179 Rome, Italy.
FAU - Filippini, Matteo
AU  - Filippini M
AD  - Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 
      Bologna, Italy.
FAU - De Vitis, Marina
AU  - De Vitis M
AD  - Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 
      Bologna, Italy.
FAU - Tessari, Alessia
AU  - Tessari A
AUID- ORCID: 0000-0002-6616-2454
AD  - Department of Psychology "Renzo Canestrari", University of Bologna, 40127 
      Bologna, Italy.
FAU - Fattori, Patrizia
AU  - Fattori P
AD  - Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 
      Bologna, Italy.
AD  - Alma Mater Research Institute for Human-Centered Artificial Intelligence (Alma 
      Human AI), University of Bologna, 40126 Bologna, Italy.
LA  - eng
GR  - MAIA-951910/European Union/
PT  - Journal Article
DEP - 20211015
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC8534070
OTO - NOTNLM
OT  - functional connectivity
OT  - medial posterior parietal cortex
OT  - paired pulse stimulation
OT  - parieto-M1 network
OT  - transcranial magnetic stimulation
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/10/15
CRDT- 2021/10/23 01:00
PHST- 2021/09/07 00:00 [received]
PHST- 2021/10/09 00:00 [revised]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/10/23 01:00 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/10/15 00:00 [pmc-release]
AID - brainsci11101357 [pii]
AID - brainsci-11-01357 [pii]
AID - 10.3390/brainsci11101357 [doi]
PST - epublish
SO  - Brain Sci. 2021 Oct 15;11(10):1357. doi: 10.3390/brainsci11101357.