PMID- 34679472
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Sep 26
TI  - Association of Adiponectin, Leptin and Resistin Plasma Concentrations with 
      Echocardiographic Parameters in Patients with Coronary Artery Disease.
LID - 10.3390/diagnostics11101774 [doi]
LID - 1774
AB  - The imbalanced network of adipokines may contribute to the development of 
      systemic low-grade inflammation, metabolic diseases and coronary artery disease 
      (CAD). In the last decade, three classic adipokines-adiponectin, leptin and 
      resistin-have been of particular interest in studies of patients with CAD due to 
      their numerous properties in relation to the cardiovascular system. This has 
      directed our attention to the association of adipokines with cardiac structure 
      and function and the development of heart failure (HF), a common end effect of 
      CAD. Thus, the purpose of this study was to analyse the associations of plasma 
      concentrations of adiponectin, leptin and resistin with parameters assessed in 
      the echocardiographic examinations of CAD patients. The presented study enrolled 
      167 Caucasian patients (133 male; 34 female) with CAD. Anthropometric, 
      echocardiographic and basic biochemical measurements, together with plasma 
      concentrations of adiponectin, leptin and resistin assays, were performed in each 
      patient. Adiponectin concentrations were negatively associated with left 
      ventricular ejection fraction (LVEF) and shortening fraction (LVSF), and 
      positively associated with mitral valve E/A ratio (E/A), left ventricular 
      end-diastolic volume (LVEDV), left ventricular end-diastolic diameter (LVEDD), 
      left ventricular end-systolic diameter LVESD, and left atrium diameter (LAD). 
      Resistin concentrations were negatively associated with E/A. Leptin 
      concentrations, although correlated with HF severity assessed by the New York 
      Heart Association (NYHA) Functional Classification, were not independently 
      associated with the echocardiographic parameters of cardiac structure or 
      function. In conclusion, adiponectin and resistin, but not leptin, are associated 
      with the echocardiographic parameters of cardiac remodelling and dysfunction. 
      These associations suggest that adiponectin and resistin might be involved in 
      mechanisms of cardiac remodelling or compensative response. We also suggest the 
      possible benefits of adiponectin and resistin level measurements in the 
      monitoring of patients with CAD.
FAU - Puchalowicz, Kamila
AU  - Puchalowicz K
AUID- ORCID: 0000-0001-8109-7112
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      70111 Szczecin, Poland.
FAU - Kloda, Karolina
AU  - Kloda K
AUID- ORCID: 0000-0003-0395-9826
AD  - Medfit Karolina Kloda, 70240 Szczecin, Poland.
FAU - Dziedziejko, Violetta
AU  - Dziedziejko V
AUID- ORCID: 0000-0003-4809-415X
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      70111 Szczecin, Poland.
FAU - Rac, Monika
AU  - Rac M
AUID- ORCID: 0000-0003-1561-346X
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      70111 Szczecin, Poland.
FAU - Wojtarowicz, Andrzej
AU  - Wojtarowicz A
AD  - Department of Cardiology, Pomeranian Medical University, 70111 Szczecin, Poland.
FAU - Chlubek, Dariusz
AU  - Chlubek D
AUID- ORCID: 0000-0003-4497-4395
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      70111 Szczecin, Poland.
FAU - Safranow, Krzysztof
AU  - Safranow K
AUID- ORCID: 0000-0001-9415-2758
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      70111 Szczecin, Poland.
LA  - eng
GR  - 002/RID/2018/19/Ministry of Science and Higher Education/
PT  - Journal Article
DEP - 20210926
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC8534895
OTO - NOTNLM
OT  - adiponectin
OT  - adipose tissue
OT  - cardiac diastolic function
OT  - cardiac remodelling
OT  - cardiac systolic function
OT  - echocardiography
OT  - heart failure
OT  - leptin
OT  - myocardial infarction
OT  - resistin
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/09/26
CRDT- 2021/10/23 01:01
PHST- 2021/09/15 00:00 [received]
PHST- 2021/09/22 00:00 [accepted]
PHST- 2021/10/23 01:01 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/09/26 00:00 [pmc-release]
AID - diagnostics11101774 [pii]
AID - diagnostics-11-01774 [pii]
AID - 10.3390/diagnostics11101774 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2021 Sep 26;11(10):1774. doi: 10.3390/diagnostics11101774.