PMID- 34679899
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Oct 1
TI  - Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues 
      in Edible Animal Tissues.
LID - 10.3390/ani11102878 [doi]
LID - 2878
AB  - Drugs are used in veterinary medicine to prevent or treat animal diseases. When 
      rationally administered to livestock following Good Veterinary Practices (GVP), 
      they greatly contribute to improving the production of food of animal origin. 
      Since humans can be exposed chronically to veterinary drugs through the diet, 
      residues in food are evaluated for effects following chronic exposures. 
      Parameters such as an acceptable daily intake (ADI), the 
      no-observed-adverse-effect level (NOAEL), maximum residue limits (MRLs), and the 
      withdrawal periods (WPs) are determined for each drug used in livestock. Drug 
      residues in food exceeding the MRLs usually appear when failing the GVP 
      application. Different factors related either to the treated animal or to the 
      type of drug administration, and even the type of cooking can affect the level of 
      residues in edible tissues. Residues above the MRLs can have a diverse negative 
      impact, mainly on the consumer's health, and favor antimicrobial resistance 
      (AMR). Drug residue monitoring programmes are crucial to ensure that prohibited 
      or authorized substances do not exceed MRLs. This comprehensive review article 
      addresses different aspects of drug residues in edible tissues produced as food 
      for human consumption and provides relevant information contributing to rational 
      pharmacotherapy in food-producing animals.
FAU - Canton, Lucila
AU  - Canton L
AD  - Laboratorio de Farmacologia, Centro de Investigacion Veterinaria de Tandil 
      (CIVETAN), UNCPBA-CICPBACONICET, Facultad de Ciencias Veterinarias, Tandil 
      CP7000, Argentina.
FAU - Lanusse, Carlos
AU  - Lanusse C
AD  - Laboratorio de Farmacologia, Centro de Investigacion Veterinaria de Tandil 
      (CIVETAN), UNCPBA-CICPBACONICET, Facultad de Ciencias Veterinarias, Tandil 
      CP7000, Argentina.
FAU - Moreno, Laura
AU  - Moreno L
AUID- ORCID: 0000-0003-3872-2853
AD  - Laboratorio de Farmacologia, Centro de Investigacion Veterinaria de Tandil 
      (CIVETAN), UNCPBA-CICPBACONICET, Facultad de Ciencias Veterinarias, Tandil 
      CP7000, Argentina.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211001
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC8532868
OTO - NOTNLM
OT  - drug regulation
OT  - drug residue effects
OT  - drug residue monitoring
OT  - drug residues in food
OT  - impact of cooking
OT  - maximum residue limits
OT  - rational use of veterinary drugs
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/10/01
CRDT- 2021/10/23 01:02
PHST- 2021/08/26 00:00 [received]
PHST- 2021/09/28 00:00 [revised]
PHST- 2021/09/30 00:00 [accepted]
PHST- 2021/10/23 01:02 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - ani11102878 [pii]
AID - animals-11-02878 [pii]
AID - 10.3390/ani11102878 [doi]
PST - epublish
SO  - Animals (Basel). 2021 Oct 1;11(10):2878. doi: 10.3390/ani11102878.