PMID- 34680155
OWN - NLM
STAT- MEDLINE
DCOM- 20220120
LR  - 20220120
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 11
IP  - 10
DP  - 2021 Oct 15
TI  - Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement.
LID - 10.3390/biom11101520 [doi]
LID - 1520
AB  - Hyperbaric oxygen treatment (HBOT)-the medical use of oxygen at environmental 
      pressure greater than one atmosphere absolute-is a very effective therapy for 
      several approved clinical situations, such as carbon monoxide intoxication, 
      incurable diabetes or radiation-injury wounds, and smoke inhalation. In recent 
      years, it has also been used to improve cognition, neuro-wellness, and quality of 
      life following brain trauma and stroke. This opens new avenues for the elderly, 
      including the treatment of neurological and neurodegenerative diseases and 
      improvement of cognition and brain metabolism in cases of mild cognitive 
      impairment. Alongside its integration into clinics, basic research studies have 
      elucidated HBOT's mechanisms of action and its effects on cellular processes, 
      transcription factors, mitochondrial function, oxidative stress, and 
      inflammation. Therefore, HBOT is becoming a major player in 21st century research 
      and clinical treatments. The following review will discuss the basic mechanisms 
      of HBOT, and its effects on cellular processes, cognition, and brain disorders.
FAU - Gottfried, Irit
AU  - Gottfried I
AD  - School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel 
      Aviv University, Tel Aviv 6997801, Israel.
FAU - Schottlender, Nofar
AU  - Schottlender N
AD  - School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel 
      Aviv University, Tel Aviv 6997801, Israel.
AD  - Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
FAU - Ashery, Uri
AU  - Ashery U
AD  - School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel 
      Aviv University, Tel Aviv 6997801, Israel.
AD  - Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211015
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Brain/drug effects/pathology
MH  - Carbon Monoxide/metabolism
MH  - Cognition/drug effects/physiology
MH  - Humans
MH  - Hyperbaric Oxygenation/*methods
MH  - Inflammation/metabolism/pathology/*therapy
MH  - Mitochondria/drug effects/metabolism
MH  - Neurodegenerative Diseases/metabolism/pathology/*therapy
MH  - Oxidative Stress/drug effects
MH  - Oxygen/*therapeutic use
MH  - Quality of Life
PMC - PMC8533945
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - brain disorders
OT  - cognition
OT  - hyperbaric oxygen treatment (HBOT)
OT  - neuroinflammation
OT  - neuroprotection
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2022/01/21 06:00
PMCR- 2021/10/15
CRDT- 2021/10/23 01:03
PHST- 2021/09/14 00:00 [received]
PHST- 2021/10/06 00:00 [revised]
PHST- 2021/10/13 00:00 [accepted]
PHST- 2021/10/23 01:03 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2022/01/21 06:00 [medline]
PHST- 2021/10/15 00:00 [pmc-release]
AID - biom11101520 [pii]
AID - biomolecules-11-01520 [pii]
AID - 10.3390/biom11101520 [doi]
PST - epublish
SO  - Biomolecules. 2021 Oct 15;11(10):1520. doi: 10.3390/biom11101520.