PMID- 34680426
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 9
IP  - 10
DP  - 2021 Sep 24
TI  - Potential Roles of Sestrin2 in Alzheimer's Disease: Antioxidation, Autophagy 
      Promotion, and Beyond.
LID - 10.3390/biomedicines9101308 [doi]
LID - 1308
AB  - Alzheimer's disease (AD) is the most common age-related neurodegenerative 
      disease. It presents with progressive memory loss, worsens cognitive functions to 
      the point of disability, and causes heavy socioeconomic burdens to patients, 
      their families, and society as a whole. The underlying pathogenic mechanisms of 
      AD are complex and may involve excitotoxicity, excessive generation of reactive 
      oxygen species (ROS), aberrant cell cycle reentry, impaired mitochondrial 
      function, and DNA damage. Up to now, there is no effective treatment available 
      for AD, and it is therefore urgent to develop an effective therapeutic regimen 
      for this devastating disease. Sestrin2, belonging to the sestrin family, can 
      counteract oxidative stress, reduce activity of the mammalian/mechanistic target 
      of rapamycin (mTOR), and improve cell survival. It may therefore play a crucial 
      role in neurodegenerative diseases like AD. However, only limited studies of 
      sestrin2 and AD have been conducted up to now. In this article, we discuss 
      current experimental evidence to demonstrate the potential roles of sestrin2 in 
      treating neurodegenerative diseases, focusing specifically on AD. Strategies for 
      augmenting sestrin2 expression may strengthen neurons, adapting them to stressful 
      conditions through counteracting oxidative stress, and may also adjust the 
      autophagy process, these two effects together conferring neuronal resistance in 
      cases of AD.
FAU - Chen, Shang-Der
AU  - Chen SD
AUID- ORCID: 0000-0001-7879-2579
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 
      83301, Taiwan.
AD  - Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial 
      Hospital, Kaohsiung City 83301, Taiwan.
FAU - Yang, Jenq-Lin
AU  - Yang JL
AUID- ORCID: 0000-0002-9897-8087
AD  - Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial 
      Hospital, Kaohsiung City 83301, Taiwan.
FAU - Hsieh, Yi-Heng
AU  - Hsieh YH
AD  - Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei City 
      11221, Taiwan.
FAU - Lin, Tsu-Kung
AU  - Lin TK
AUID- ORCID: 0000-0001-6656-1319
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 
      83301, Taiwan.
AD  - College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
AD  - Center for Mitochondrial Research and Medicine, Kaohsiung Chang Gung Memorial 
      Hospital, Chang Gung University College of Medicine, Kaohsiung City 80708, 
      Taiwan.
FAU - Lin, Yi-Chun
AU  - Lin YC
AD  - Department of Neurology, Taipei City Hospital, Taipei City 10629, Taiwan.
FAU - Chao, A-Ching
AU  - Chao AC
AUID- ORCID: 0000-0003-1230-9622
AD  - Department of Neurology, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung City 80708, Taiwan.
AD  - Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung City 
      80756, Taiwan.
FAU - Yang, Ding-I
AU  - Yang DI
AUID- ORCID: 0000-0001-5544-7561
AD  - Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei City 
      11221, Taiwan.
AD  - Brain Research Center, National Yang Ming Chiao Tung University, Taipei City 
      11221, Taiwan.
LA  - eng
GR  - MOST 104-2314-B-010-014-MY2, MOST 107-2314-B-010-020-MY3, MOST 109-2314-B-010- 
      038-MY3; MOST 108-2314-B-037-038-MY3; MOST 109-2314-B-182A-078-MY3; MOST 
      108-2320-B-182A-005-MY3/Ministry of Science and Technology, Taiwan/
GR  - 11001-62-038/Department of Health in Taipei City Government/
GR  - CMRPG8I0051, CMRPG8I0052, CMRPG8I0053; CMRPG8K0652/Chang Gung Medical Foundation/
GR  - KMUH109-9R72/Kaohsiung Medical University Hospital/
GR  - 110BRC-B407/Ministry of Education, Taiwan/
PT  - Journal Article
PT  - Review
DEP - 20210924
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC8533411
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - autophagy
OT  - mTOR
OT  - oxidative stress
OT  - sestrin2
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/09/24
CRDT- 2021/10/23 01:04
PHST- 2021/07/29 00:00 [received]
PHST- 2021/09/14 00:00 [revised]
PHST- 2021/09/16 00:00 [accepted]
PHST- 2021/10/23 01:04 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/09/24 00:00 [pmc-release]
AID - biomedicines9101308 [pii]
AID - biomedicines-09-01308 [pii]
AID - 10.3390/biomedicines9101308 [doi]
PST - epublish
SO  - Biomedicines. 2021 Sep 24;9(10):1308. doi: 10.3390/biomedicines9101308.