PMID- 34680602
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 9
IP  - 10
DP  - 2021 Oct 16
TI  - Surface Modification of Porous Polyethylene Implants with an Albumin-Based 
      Nanocarrier-Release System.
LID - 10.3390/biomedicines9101485 [doi]
LID - 1485
AB  - BACKGROUND: Porous polyethylene (PPE) implants are used for the reconstruction of 
      tissue defects but have a risk of rejection in case of insufficient ingrowth into 
      the host tissue. Various growth factors can promote implant ingrowth, yet a 
      long-term gradient is a prerequisite for the mediation of these effects. As 
      modification of the implant surface with nanocarriers may facilitate a long-term 
      gradient by sustained factor release, implants modified with crosslinked albumin 
      nanocarriers were evaluated in vivo. METHODS: Nanocarriers from murine serum 
      albumin (MSA) were prepared by an inverse miniemulsion technique encapsulating 
      either a low- or high-molar mass fluorescent cargo. PPE implants were 
      subsequently coated with these nanocarriers. In control cohorts, the implant was 
      coated with the homologue non-encapsulated cargo substance by dip coating. 
      Implants were consequently analyzed in vivo using repetitive fluorescence 
      microscopy utilizing the dorsal skinfold chamber in mice for ten days post 
      implantation. RESULTS: Implant-modification with MSA nanocarriers significantly 
      prolonged the presence of the encapsulated small molecules while macromolecules 
      were detectable during the investigated timeframe regardless of the form of 
      application. CONCLUSIONS: Surface modification of PPE implants with MSA 
      nanocarriers results in the alternation of release kinetics especially when small 
      molecular substances are used and therefore allows a prolonged factor release for 
      the promotion of implant integration.
FAU - Eckrich, Jonas
AU  - Eckrich J
AUID- ORCID: 0000-0001-5498-4031
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, 
      Langenbeckstrasse 1, 55131 Mainz, Germany.
AD  - Department of Otorhinolaryngology, University Medical Center Bonn (UKB), 
      Venusberg-Campus 1, 53127 Bonn, Germany.
FAU - Hoormann, Niklas
AU  - Hoormann N
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, 
      Langenbeckstrasse 1, 55131 Mainz, Germany.
FAU - Kersten, Erik
AU  - Kersten E
AD  - Max Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, 
      Germany.
FAU - Piradashvili, Keti
AU  - Piradashvili K
AD  - Max Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, 
      Germany.
FAU - Wurm, Frederik R
AU  - Wurm FR
AD  - Max Planck Institute for Polymer Research (MPIP), Ackermannweg 10, 55128 Mainz, 
      Germany.
AD  - Sustainable Polymer Chemistry, Department of Molecules and Materials, MESA+ 
      Institute for Nanotechnology, Faculty of Science and Technology, Universiteit 
      Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
FAU - Heller, Martin
AU  - Heller M
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, 
      Langenbeckstrasse 1, 55131 Mainz, Germany.
FAU - Becker, Sven
AU  - Becker S
AUID- ORCID: 0000-0003-1972-3797
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University of Tubingen, 
      Elfriede-Aulhorn-Str. 5, 72076 Tubingen, Germany.
FAU - Anusic, Toni
AU  - Anusic T
AD  - Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), 
      University Medical Center, Obere Zahlbacher Str. 69, 55131 Mainz, Germany.
FAU - Brieger, Juergen
AU  - Brieger J
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, 
      Langenbeckstrasse 1, 55131 Mainz, Germany.
FAU - Strieth, Sebastian
AU  - Strieth S
AUID- ORCID: 0000-0003-0177-1926
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, 
      Langenbeckstrasse 1, 55131 Mainz, Germany.
AD  - Department of Otorhinolaryngology, University Medical Center Bonn (UKB), 
      Venusberg-Campus 1, 53127 Bonn, Germany.
LA  - eng
GR  - No Grant Nr. avaliable (intramural funding)/Universitatsmedizin der Johannes 
      Gutenberg-Universitat Mainz/
PT  - Journal Article
DEP - 20211016
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC8533240
OTO - NOTNLM
OT  - albumin nanocarriers
OT  - biomaterial
OT  - dorsal skinfold chamber
OT  - fluorescence microscopy
OT  - material science
OT  - porous polyethylene
OT  - release kinetics
OT  - tissue engineering
COIS- The authors declare no conflict of interest. The study received financial support 
      from the focus program BiomaTiCS of the University medical center Mainz. The 
      funders had no role in the design of the study; in the collection, analyses, or 
      interpretation of data; in the writing of the manuscript, or in the decision to 
      publish the results.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/10/16
CRDT- 2021/10/23 01:04
PHST- 2021/08/31 00:00 [received]
PHST- 2021/09/27 00:00 [revised]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/10/23 01:04 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/10/16 00:00 [pmc-release]
AID - biomedicines9101485 [pii]
AID - biomedicines-09-01485 [pii]
AID - 10.3390/biomedicines9101485 [doi]
PST - epublish
SO  - Biomedicines. 2021 Oct 16;9(10):1485. doi: 10.3390/biomedicines9101485.