PMID- 34681058
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2079-7737 (Print)
IS  - 2079-7737 (Electronic)
IS  - 2079-7737 (Linking)
VI  - 10
IP  - 10
DP  - 2021 Sep 26
TI  - Prevalence of Hyperhomocysteinemia in China: An Updated Meta-Analysis.
LID - 10.3390/biology10100959 [doi]
LID - 959
AB  - We conducted a meta-analysis to systematically assess the prevalence of 
      hyperhomocysteinemia (HHcy) in China, its change over time, and its determinants. 
      Literature searches were conducted using English databases (PubMed, Embase, and 
      Web of Science) and Chinese databases (CNKI, CBM, VIP, and Wanfang). The time 
      ranges were from Jan 2014 to Mar 2021 in China. We adopted the random effects 
      model to estimate the pooled positive rates of HHcy and corresponding 95% 
      confidence intervals (95% CI). To find the sources of heterogeneity, we performed 
      subgroup analysis and meta-regression. A total of 29 related articles were 
      identified involving 338,660 participants with 128,147 HHcy cases. The estimated 
      prevalence of HHcy in China was 37.2% (95% CI: 32.6-41.8%, I(2) = 99.8%, p for 
      heterogeneity < 0.001). The trend of HHcy prevalence was gradually upward over 
      time, with increases during 2015-2016 (comparison to 2013-2014, p < 0.001), but 
      steady between 2015-2016 and 2017-2018. Subgroup analysis showed that the 
      prevalence was higher in the elderly over 55 years old, males, and residents in 
      the north, inland, and rural China (for each comparison, p < 0.001). 
      Meta-regression analysis revealed that age and area of study contributed to 42.3% 
      of the heterogeneity between studies. The current meta-analysis provides strong 
      evidence that the prevalence of HHcy is increasing in China, and varies 
      substantially across different ages, genders, and geographic distribution. 
      Accordingly, high-risk population groups should be focused on, and public health 
      policies and strategies should be carried out to prevent and control HHcy in 
      China.
FAU - Zeng, Yuan
AU  - Zeng Y
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha 410081, China.
FAU - Li, Fei-Fei
AU  - Li FF
AD  - Centre for Health and Exercise Science Research, Hong Kong Baptist University, 
      Kowloon Tong, Hong Kong 999077, China.
AD  - Centre for Health and Exercise Science Research, Department of Sport, Physical 
      Education and Health, Hong Kong Baptist University, Kowloon Tong, Hong Kong 
      999077, China.
FAU - Yuan, Shu-Qian
AU  - Yuan SQ
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha 410081, China.
FAU - Tang, Hao-Kai
AU  - Tang HK
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha 410081, China.
FAU - Zhou, Jun-Hua
AU  - Zhou JH
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha 410081, China.
FAU - He, Quan-Yuan
AU  - He QY
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha 410081, China.
FAU - Baker, Julien S
AU  - Baker JS
AUID- ORCID: 0000-0002-9093-7897
AD  - Centre for Health and Exercise Science Research, Hong Kong Baptist University, 
      Kowloon Tong, Hong Kong 999077, China.
AD  - Centre for Health and Exercise Science Research, Department of Sport, Physical 
      Education and Health, Hong Kong Baptist University, Kowloon Tong, Hong Kong 
      999077, China.
FAU - Dong, Yan-Hui
AU  - Dong YH
AUID- ORCID: 0000-0003-2519-3200
AD  - Institute of Child and Adolescent Health, School of Public Health, Peking 
      University Health Science Center, Beijing 100191, China.
FAU - Yang, Yi-De
AU  - Yang YD
AUID- ORCID: 0000-0003-3297-1306
AD  - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, 
      Hunan Normal University, Changsha 410081, China.
LA  - eng
GR  - 81903336/National Natural Science Foundation of China/
GR  - 2019JJ50376/Hunan Provincial Natural Science Foundation of China/
GR  - 202112031516/Scientific Research Project of Hunan Health Committee/
GR  - S202110542057/Hunan province college students research learning and innovative 
      experiment project/
GR  - 2020SK1015-3/Key Project of Hunan Provincial Science and Technology Innovation/
PT  - Journal Article
PT  - Review
DEP - 20210926
PL  - Switzerland
TA  - Biology (Basel)
JT  - Biology
JID - 101587988
PMC - PMC8533293
OTO - NOTNLM
OT  - China
OT  - hyperhomocysteinemia
OT  - prevalence
OT  - updated meta-analysis
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/09/26
CRDT- 2021/10/23 01:06
PHST- 2021/07/27 00:00 [received]
PHST- 2021/09/13 00:00 [revised]
PHST- 2021/09/23 00:00 [accepted]
PHST- 2021/10/23 01:06 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/09/26 00:00 [pmc-release]
AID - biology10100959 [pii]
AID - biology-10-00959 [pii]
AID - 10.3390/biology10100959 [doi]
PST - epublish
SO  - Biology (Basel). 2021 Sep 26;10(10):959. doi: 10.3390/biology10100959.