PMID- 34681579
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 20
DP  - 2021 Oct 9
TI  - d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.
LID - 10.3390/ijms222010917 [doi]
LID - 10917
AB  - Numerous studies over the last several years have shown that d-amino acids, 
      especially d-serine, have been related to brain and neurological disorders. 
      Acknowledged neurological functions of d-amino acids include neurotransmission 
      and learning and memory functions through modulating N-methyl-d-aspartate type 
      glutamate receptors (NMDARs). Aberrant d-amino acids level and polymorphisms of 
      genes related to d-amino acids metabolism are associated with neurodegenerative 
      brain conditions. This review summarizes the roles of d-amino acids and pLG72, 
      also known as d-amino acid oxidase activator, on two neurodegenerative disorders, 
      schizophrenia and Alzheimer's disease (AD). The scope includes the changes in 
      d-amino acids levels, gene polymorphisms of G72 genomics, and the role of pLG72 
      on NMDARs and mitochondria in schizophrenia and AD. The clinical diagnostic value 
      of d-amino acids and pLG72 and the therapeutic importance are also reviewed.
FAU - Cheng, Yu-Jung
AU  - Cheng YJ
AD  - Department of Physical Therapy, Graduate Institute of Rehabilitation Science, 
      China Medical University, Taichung 40402, Taiwan.
AD  - Department of Rehabilitation, China Medical University Hospital, Taichung 40402, 
      Taiwan.
FAU - Lin, Chieh-Hsin
AU  - Lin CH
AD  - Institute of Clinical Medical Science, China Medical University, Taichung 40402, 
      Taiwan.
AD  - Graduate Institute of Biomedical Sciences, China Medical University, Taichung 
      40402, Taiwan.
AD  - Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung 
      University College of Medicine, Kaohsiung 83301, Taiwan.
AD  - School of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
FAU - Lane, Hsien-Yuan
AU  - Lane HY
AUID- ORCID: 0000-0003-2162-8174
AD  - Institute of Clinical Medical Science, China Medical University, Taichung 40402, 
      Taiwan.
AD  - Graduate Institute of Biomedical Sciences, China Medical University, Taichung 
      40402, Taiwan.
AD  - Department of Psychiatry & Brain Disease Research Center, China Medical 
      University Hospital, Taichung 40402, Taiwan.
AD  - Department of Psychology, College of Medical and Health Sciences, Asia 
      University, Taichung 41354, Taiwan.
LA  - eng
GR  - NHRI-EX109-10731NI/National Health Research Institutes/
GR  - NHRI-EX110- 10816NC/National Health Research Institutes/
GR  - MOST 108-2410-H-039-009-MY2/Ministry of Science and Technology, Taiwan/
GR  - 109-2628-B-182A-002/Ministry of Science and Technology, Taiwan/
GR  - 109-2314-B-039-039-MY3/Ministry of Science and Technology, Taiwan/
GR  - 109-2314-B-039 -001/Ministry of Science and Technology, Taiwan/
GR  - 110-2314-B-182A-048/Ministry of Science and Technology, Taiwan/
GR  - 110-2622-B039-001/Ministry of Science and Technology, Taiwan/
GR  - CMRPG8G1391/Chang Gung Memorial Hospital, Linkou/
GR  - CMRPG8K1162/Chang Gung Memorial Hospital, Linkou/
GR  - CMRPG8K1461/Chang Gung Memorial Hospital, Linkou/
GR  - CMU107-S-25/China Medical University, Taiwan/
PT  - Journal Article
PT  - Review
DEP - 20211009
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Amino Acids)
RN  - 0 (DAOA protein, human)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Alzheimer Disease/diagnosis/genetics/*metabolism
MH  - Amino Acids/*metabolism
MH  - Brain/metabolism
MH  - Early Diagnosis
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*genetics/metabolism
MH  - Mitochondria/metabolism
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Schizophrenia/diagnosis/genetics/*metabolism
PMC - PMC8535920
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - d-amino acids
OT  - pLG72
OT  - schizophrenia
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/10/09
CRDT- 2021/10/23 01:07
PHST- 2021/08/30 00:00 [received]
PHST- 2021/10/01 00:00 [revised]
PHST- 2021/10/06 00:00 [accepted]
PHST- 2021/10/23 01:07 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/10/09 00:00 [pmc-release]
AID - ijms222010917 [pii]
AID - ijms-22-10917 [pii]
AID - 10.3390/ijms222010917 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Oct 9;22(20):10917. doi: 10.3390/ijms222010917.