PMID- 34682098
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 8
IP  - 10
DP  - 2021 Sep 23
TI  - Head Growth and Neurodevelopment of Preterm Infants with Surgical Necrotizing 
      Enterocolitis and Spontaneous Intestinal Perforation.
LID - 10.3390/children8100833 [doi]
LID - 833
AB  - Spontaneous intestinal perforation (SIP) and surgical necrotizing enterocolitis 
      (NEC) are intestinal conditions requiring surgical intervention in preterm 
      infants. We aimed to compare the head growth and neurodevelopment of preterm 
      infants with SIP and surgical NEC. A retrospective single-center study was 
      performed in preterm infants born at less than 32 weeks of gestation and who had 
      undergone surgery for NEC or SIP. Data from the Bayley Scales of Infant and 
      Toddler Development 3rd Edition (Bayley-III) at 24 months of corrected age (CA) 
      and the Korean Ages and Stages Questionnaire (K-ASQ) or Korean Developmental 
      Screening Test (K-DST) at 36 months were collected. Among 82 eligible infants, 60 
      infants had surgical NEC, and 22 infants were diagnosed with SIP. Head growth was 
      faster until CA 4 months in preterm infants with SIP than in those with surgical 
      NEC. At 36 months, abnormal findings in the K-ASQ or K-DST were more prevalent in 
      the NEC group than in the SIP group in the gross motor (48.2% vs. 0%, p = 0.015), 
      fine motor (40.7% vs. 0%, p = 0.037), cognitive (55.6% vs. 12.5%, p = 0.047), and 
      social domains (44.4% vs. 0%, p = 0.032). More studies evaluating the 
      neurodevelopmental outcomes of preterm infants with surgical NEC and SIP are 
      required.
FAU - Shin, Seung-Han
AU  - Shin SH
AUID- ORCID: 0000-0002-1469-589X
AD  - Department of Pediatrics, College of Medicine, Seoul National University, Seoul 
      03080, Korea.
FAU - Kim, Ee-Kyung
AU  - Kim EK
AUID- ORCID: 0000-0002-7063-168X
AD  - Department of Pediatrics, College of Medicine, Seoul National University, Seoul 
      03080, Korea.
FAU - Kim, Seh-Hyun
AU  - Kim SH
AD  - Department of Pediatrics, College of Medicine, Seoul National University, Seoul 
      03080, Korea.
FAU - Kim, Hyun-Young
AU  - Kim HY
AD  - Department of Pediatric Surgery, Seoul National University College of Medicine, 
      Seoul 03080, Korea.
FAU - Kim, Han-Suk
AU  - Kim HS
AD  - Department of Pediatrics, College of Medicine, Seoul National University, Seoul 
      03080, Korea.
LA  - eng
GR  - NRF-2020R1F1A1077268/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20210923
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC8534747
OTO - NOTNLM
OT  - necrotizing enterocolitis
OT  - neurodevelopment
OT  - preterm infants
OT  - spontaneous intestinal perforation
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/09/23
CRDT- 2021/10/23 01:10
PHST- 2021/08/11 00:00 [received]
PHST- 2021/09/16 00:00 [revised]
PHST- 2021/09/17 00:00 [accepted]
PHST- 2021/10/23 01:10 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/09/23 00:00 [pmc-release]
AID - children8100833 [pii]
AID - children-08-00833 [pii]
AID - 10.3390/children8100833 [doi]
PST - epublish
SO  - Children (Basel). 2021 Sep 23;8(10):833. doi: 10.3390/children8100833.