PMID- 34682178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 8
IP  - 10
DP  - 2021 Oct 13
TI  - Characteristics of Kawasaki Disease Patients during the COVID-19 Pandemic in 
      Japan: A Single-Center, Observational Study.
LID - 10.3390/children8100913 [doi]
LID - 913
AB  - BACKGROUND: Under the Coronavirus disease 2019 (COVID-19) pandemic, 
      manifestations in children with Kawasaki disease (KD) are different between the 
      Western and the Eastern countries. Particularly, there has not been a report 
      comparing a series of KD in Japan, where KD was originally discovered and has a 
      large number of registered cases. METHODS: We compared patients with KD under the 
      period of the COVID-19 pandemic in Japan with the report from Italy during its 
      reported period by a retrospective, cohort, observational study in a Japanese 
      single center. RESULTS: Thirty-two patients with typical KD were treated during 
      the study period, while the Italian study reported 10 patients with the signs of 
      KD. Concerning the proof of severe acute respiratory syndrome coronavirus type 2 
      (SARS-CoV-2) infection, none (0%) of our KD cases showed a positive result and 
      one and no patients developed the macrophage activation syndrome (MAS) and 
      Kawasaki disease shock syndrome (KDSS), respectively; however, eight (80%) 
      patients in the Italian series were confirmed with SARS-CoV-2 infection. MAS and 
      KDSS developed in six and five patients, respectively. CONCLUSIONS: Cases 
      reported as COVID-19 pandemic-related KD in Italy showed significantly different 
      clinical characteristics from the typical KD symptoms known in Japan. Although 
      they show KD-like manifestations, we cannot conclude that SARS-CoV-2 has the same 
      etiology of our 'classic' KD at the present stage.
FAU - Shimizu, Shoichi
AU  - Shimizu S
AUID- ORCID: 0000-0001-5962-4932
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Ayusawa, Mamoru
AU  - Ayusawa M
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Go, Hidetoshi
AU  - Go H
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Nakazaki, Kimitaka
AU  - Nakazaki K
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Namiki, Hidemasa
AU  - Namiki H
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Kasuga, Yuki
AU  - Kasuga Y
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Nishimura, Koji
AU  - Nishimura K
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Kanezawa, Koji
AU  - Kanezawa K
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Morohashi, Tamaki
AU  - Morohashi T
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
FAU - Morioka, Ichiro
AU  - Morioka I
AUID- ORCID: 0000-0002-5685-2670
AD  - Department of Pediatrics and Child Health, Nihon University School of Medicine, 
      Tokyo 173-8610, Japan.
LA  - eng
PT  - Journal Article
DEP - 20211013
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC8535006
OTO - NOTNLM
OT  - Japan
OT  - Kawasaki disease
OT  - coronavirus disease 2019
OT  - pandemic
OT  - severe acute respiratory syndrome coronavirus type 2
OT  - vasculitis
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/10/13
CRDT- 2021/10/23 01:10
PHST- 2021/09/21 00:00 [received]
PHST- 2021/10/10 00:00 [revised]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/23 01:10 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/10/13 00:00 [pmc-release]
AID - children8100913 [pii]
AID - children-08-00913 [pii]
AID - 10.3390/children8100913 [doi]
PST - epublish
SO  - Children (Basel). 2021 Oct 13;8(10):913. doi: 10.3390/children8100913.