PMID- 34682470
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 20
DP  - 2021 Oct 13
TI  - Correlation between Severity of Fetal Growth Restriction and Oxidative Stress in 
      Severe Small-for-Gestational-Age Infants.
LID - 10.3390/ijerph182010726 [doi]
LID - 10726
AB  - Severe small-for-gestational-age (sSGA) infants exhibit increased mortality and 
      morbidity. Oxidative stress is suggested to be involved in intrauterine growth 
      restriction. This retrospective study aimed to evaluate the oxidative stress 
      level at birth in an sSGA population. Sera of 28 sSGA (sSGA group) and 31 
      non-sSGA (control group) infants, born at our hospital between March 2017 and 
      March 2020, were evaluated. Oxidative stress (derivative of reactive oxidative 
      metabolites: d-ROM level), biological antioxidant potential (BAP) level, and the 
      ratio of d-ROM/BAP level (oxidative stress index: OSI) were measured. The sSGA 
      group had a significantly lower birth weight (BW), BW z-score, head 
      circumference, and height than the control group (all p < 0.05). No significant 
      difference was noted in the BAP level; sSGA infants exhibited a significantly 
      higher d-ROM level than control infants. sSGA infants showed a significantly 
      increased OSI compared with control infants, and the BW z-score was inversely 
      correlated with d-ROM levels and OSI in sSGA infants (R(2) = 0.300; p < 0.01 and 
      R(2) = 0.319; p = 0.02, respectively) but not in controls. In conclusion, sSGA 
      infants, including preterm infants, exhibited higher oxidative stress at birth. 
      The severity of fetal growth restriction was significantly correlated with 
      oxidative stress levels at birth in sSGA infants.
FAU - Ashina, Mariko
AU  - Ashina M
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Kido, Takumi
AU  - Kido T
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Kyono, Yuki
AU  - Kyono Y
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Yoshida, Asumi
AU  - Yoshida A
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Suga, Shutaro
AU  - Suga S
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Nakasone, Ruka
AU  - Nakasone R
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Abe, Shinya
AU  - Abe S
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Tanimura, Kenji
AU  - Tanimura K
AD  - Department of Obstetrics and Gynecology, Kobe University Graduate School of 
      Medicine, Kobe 6500017, Japan.
FAU - Nozu, Kandai
AU  - Nozu K
AUID- ORCID: 0000-0002-0290-3137
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
FAU - Fujioka, Kazumichi
AU  - Fujioka K
AUID- ORCID: 0000-0002-9913-6447
AD  - Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 
      6500017, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211013
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Birth Weight
MH  - Female
MH  - *Fetal Growth Retardation
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Infant, Small for Gestational Age
MH  - Oxidative Stress
MH  - Retrospective Studies
PMC - PMC8535480
OTO - NOTNLM
OT  - fetal growth restriction
OT  - oxidative stress
OT  - small for gestational age
OT  - z-score
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2021/10/24 06:00
MHDA- 2021/11/03 06:00
PMCR- 2021/10/13
CRDT- 2021/10/23 01:11
PHST- 2021/08/17 00:00 [received]
PHST- 2021/10/11 00:00 [revised]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/10/23 01:11 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/10/13 00:00 [pmc-release]
AID - ijerph182010726 [pii]
AID - ijerph-18-10726 [pii]
AID - 10.3390/ijerph182010726 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Oct 13;18(20):10726. doi: 
      10.3390/ijerph182010726.