PMID- 34683101
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Sep 27
TI  - Capsaicin 8% Patch and Chronic Postsurgical Neuropathic Pain.
LID - 10.3390/jpm11100960 [doi]
LID - 960
AB  - (1) Background: Surgery is a frequent cause of persistent pain, defined chronic 
      post-surgical pain (CPSP). The capsaicin 8% patch (Qutenza((R))) is approved for 
      the treatment of postherpetic neuralgia (PHN) and for diabetic peripheral 
      neuropathy (DPN) of the feet. We propose a review of the literature on use of the 
      capsaicin 8% patch to treat neuropathic pain associated with surgery; (2) 
      Methods: We identified the articles by searching electronic databases using a 
      combination of such terms as "capsaicin 8% patch", "Qutenza((R))", and "chronic 
      postsurgical pain"; (3) Results: We identified 14 selected studies reporting on a 
      total of 632 CPSP cases treated with capsaicin 8% patch. Treatment with the 
      capsaicin 8% patch significantly reduced the average pain intensity. Only 5 
      studies reported adverse events (AEs) after the patch application. The most 
      common AEs were erythema, burning sensation and pain; (4) Conclusions: Our review 
      indicate that capsaicin 8% patch treatment for CPSP is effective, safe and well 
      tolerated, but randomized controlled trials on efficacy, safety and tolerability 
      should be conducted.
FAU - Giaccari, Luca Gregorio
AU  - Giaccari LG
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Aurilio, Caterina
AU  - Aurilio C
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Coppolino, Francesco
AU  - Coppolino F
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Pace, Maria Caterina
AU  - Pace MC
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Passsavanti, Maria Beatrice
AU  - Passsavanti MB
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Pota, Vincenzo
AU  - Pota V
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
FAU - Sansone, Pasquale
AU  - Sansone P
AUID- ORCID: 0000-0003-0873-3586
AD  - Department of Woman, Child and General and Specialized Surgery, University of 
      Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210927
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC8537698
OTO - NOTNLM
OT  - Qutenza(R)
OT  - capsaicin 8% patch
OT  - chronic post-surgical pain (CPSP)
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/09/27
CRDT- 2021/10/23 01:14
PHST- 2021/09/04 00:00 [received]
PHST- 2021/09/23 00:00 [revised]
PHST- 2021/09/25 00:00 [accepted]
PHST- 2021/10/23 01:14 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/09/27 00:00 [pmc-release]
AID - jpm11100960 [pii]
AID - jpm-11-00960 [pii]
AID - 10.3390/jpm11100960 [doi]
PST - epublish
SO  - J Pers Med. 2021 Sep 27;11(10):960. doi: 10.3390/jpm11100960.