PMID- 34683415
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2076-2607 (Print)
IS  - 2076-2607 (Electronic)
IS  - 2076-2607 (Linking)
VI  - 9
IP  - 10
DP  - 2021 Oct 3
TI  - Alleviation Effects of Bifidobacterium animalis subsp. lactis XLTG11 on Dextran 
      Sulfate Sodium-Induced Colitis in Mice.
LID - 10.3390/microorganisms9102093 [doi]
LID - 2093
AB  - Inflammatory bowel disease (IBD) is a chronic immune-related disease, which can 
      occur through the dysfunction of the immune system caused by the imbalance of gut 
      microbiota. Previous studies have reported the beneficial effects of 
      Bifidobacterium on colitis, while the related mechanisms behind these effects 
      have not been fully elucidated. The aim of our study is to investigate the 
      alleviation effect of Bifidobacterium animalis subsp. lactis XLTG11 (B. lactis) 
      on dextran sulfate sodium (DSS)-induced colitis and its potential mechanism. The 
      results showed that B. lactis XLTG11 significantly decreased weight loss, disease 
      activity index score, colon shortening, myeloperoxide activity, spleen weight, 
      and colon tissue damage. Additionally, B. lactis XLTG11 significantly decreased 
      the levels of pro-inflammatory cytokines and increased the level of 
      anti-inflammatory cytokine. Meanwhile, high doses of B. lactis XLTG11 
      significantly up-regulated the expression of tight junction proteins and 
      inhibited activation of Toll-like receptor 4 (TLR4)/myeloid differentiation 
      factor 88 (MYD88)/nuclear factor-kappaB (NF-kappaB) signaling pathway. Furthermore, B. 
      lactis XLTG11 increased the gut microbiota diversity and modulated gut microbiota 
      composition caused by DSS. Moreover, Spearman's correlation analysis also found 
      that several specific gut microbiota were significantly correlated with 
      colitis-related indicators. These results demonstrated that B. lactis XLTG11 can 
      alleviate DSS-induced colitis by inhibiting the activation of the 
      TLR4/MYD88/NF-kappaB signaling pathway, regulating inflammatory cytokines, improving 
      intestinal barrier function, and modulating the gut microbiota.
FAU - Wang, Nana
AU  - Wang N
AD  - Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural 
      University, Harbin 150030, China.
AD  - Food College, Northeast Agricultural University, Harbin 150030, China.
FAU - Wang, Song
AU  - Wang S
AUID- ORCID: 0000-0002-3710-8213
AD  - Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural 
      University, Harbin 150030, China.
AD  - Food College, Northeast Agricultural University, Harbin 150030, China.
FAU - Xu, Baofeng
AU  - Xu B
AD  - Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural 
      University, Harbin 150030, China.
AD  - Food College, Northeast Agricultural University, Harbin 150030, China.
FAU - Liu, Fei
AU  - Liu F
AD  - Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural 
      University, Harbin 150030, China.
AD  - Food College, Northeast Agricultural University, Harbin 150030, China.
FAU - Huo, Guicheng
AU  - Huo G
AD  - Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural 
      University, Harbin 150030, China.
AD  - Food College, Northeast Agricultural University, Harbin 150030, China.
FAU - Li, Bailiang
AU  - Li B
AD  - Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural 
      University, Harbin 150030, China.
AD  - Food College, Northeast Agricultural University, Harbin 150030, China.
LA  - eng
GR  - CNS-Feihe2020A37/Chinese nutrition society - Feihe physique nutrition and health 
      research fund/
GR  - No. 2020ZX07B01/Hundred, Thousand and Ten Thousand" Science and Technology Major 
      Special Project of Hei-longjiang Province: Dairy Products and Meat Processing/
GR  - 32072190/the National Natural Science Foundation of China/
GR  - No. 19YJXG10/Academic Backbone Plan of Northeast Agricultural University/
PT  - Journal Article
DEP - 20211003
PL  - Switzerland
TA  - Microorganisms
JT  - Microorganisms
JID - 101625893
PMC - PMC8539219
OTO - NOTNLM
OT  - Bifidobacterium animalis subsp. lactis
OT  - colitis
OT  - gut microbiota
OT  - inflammation
OT  - tight junction proteins
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/10/03
CRDT- 2021/10/23 01:15
PHST- 2021/07/30 00:00 [received]
PHST- 2021/09/29 00:00 [revised]
PHST- 2021/09/30 00:00 [accepted]
PHST- 2021/10/23 01:15 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/10/03 00:00 [pmc-release]
AID - microorganisms9102093 [pii]
AID - microorganisms-09-02093 [pii]
AID - 10.3390/microorganisms9102093 [doi]
PST - epublish
SO  - Microorganisms. 2021 Oct 3;9(10):2093. doi: 10.3390/microorganisms9102093.