PMID- 34684176 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211026 IS - 2076-0817 (Print) IS - 2076-0817 (Electronic) IS - 2076-0817 (Linking) VI - 10 IP - 10 DP - 2021 Sep 23 TI - The Prevalence and Serological Association of Hepatitis D Virus Genotypes in Taiwan. LID - 10.3390/pathogens10101227 [doi] LID - 1227 AB - Hepatitis Delta Virus (HDV) is an RNA virus that requires the presence of hepatitis B surface antigen (HBsAg) to propagate into hepatocytes, with Genotype I being more prevalent globally. However, the prevalence of HDV genotypes in Taiwan is unknown. Accordingly, a cohort including 24 chronic HBV patients who received nucleos(t)ides (NUCs) between January 2002 and July 2018 was used to determine HDV genotypes and genotype specific serological association in chronic HBV carriers. HDV-positive genotypes in 18/24 (75%) males and 6/24 (25%) females were identified among chronic HBV patients. Viremia was lower in HDV-IV patients than in patients affected with other HDV genotypes (1.34 log(10) copies/mL vs. 3.30 log(10) copies/mL; p = 0.009). A logistics regression analysis revealed that HDV-IV was inversely proportional to HDV RNA (odds ratio [OR]/95% confidence intervals [CI]: 0.370/0.164-0.830; p = 0.017). The serologic association study indicated lower levels of creatinine (p = 0.047) and HDV-RNA (p = 0.009) in the HDV-IV group than the non-HDV-IV group but did not indicate any significant differences in the AST, ALT, bilirubin levels or other laboratory test factors. The three genotypes evident in Taiwan were HDV-I (4/24, 16.7%), HDV-II (6/24, 25.0%), and HDV-IV (14/24, 58.3%), and HDV-IV is the predominant HDV genotype in Taiwan. These results anticipate a clear understanding of HDV genotype serological association in chronic HBV carriers. FAU - Joseph, Keva AU - Joseph K AUID- ORCID: 0000-0001-8609-464X AD - M. Sc. Program in Tropical Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Shabangu, Ciniso Sylvester AU - Shabangu CS AUID- ORCID: 0000-0001-5954-4254 AD - Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Jang, Tyng-Yuan AU - Jang TY AUID- ORCID: 0000-0003-2961-130X AD - Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Huang, Chung-Feng AU - Huang CF AUID- ORCID: 0000-0002-3367-068X AD - Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Dai, Chia-Yen AU - Dai CY AUID- ORCID: 0000-0003-2296-3054 AD - Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Huang, Jee-Fu AU - Huang JF AD - Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Chuang, Wan-Long AU - Chuang WL AUID- ORCID: 0000-0002-2376-421X AD - Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Hepatitis Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Yu, Ming-Lung AU - Yu ML AUID- ORCID: 0000-0001-8145-1900 AD - Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Faculty of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Hepatitis Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. FAU - Wang, Shu-Chi AU - Wang SC AUID- ORCID: 0000-0001-9691-7507 AD - Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Center for Liquid Biopsy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. AD - Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan. AD - Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. LA - eng GR - KMU-KI110002/Kaohsiung Medical University/ GR - KMU-TC109B05/Kaohsiung Medical University/ GR - KMU-TC109A04/Kaohsiung Medical University/ GR - 110-2314-B-037-119/Ministry of Science and Technology, Taiwan/ GR - KMUH-DK109005-1/Kaohsiung Medical University Chung-Ho Memorial Hospital/ GR - KMUH-DK109002/Kaohsiung Medical University Chung-Ho Memorial Hospital/ GR - KMUH-DK(C)110011/Kaohsiung Medical University Chung-Ho Memorial Hospital/ PT - Journal Article DEP - 20210923 PL - Switzerland TA - Pathogens JT - Pathogens (Basel, Switzerland) JID - 101596317 PMC - PMC8541235 OTO - NOTNLM OT - HBV OT - HDV genotype OT - clinical significance OT - dual infection COIS- The authors declare no conflict of interest. EDAT- 2021/10/24 06:00 MHDA- 2021/10/24 06:01 PMCR- 2021/09/23 CRDT- 2021/10/23 01:17 PHST- 2021/08/27 00:00 [received] PHST- 2021/09/17 00:00 [revised] PHST- 2021/09/19 00:00 [accepted] PHST- 2021/10/23 01:17 [entrez] PHST- 2021/10/24 06:00 [pubmed] PHST- 2021/10/24 06:01 [medline] PHST- 2021/09/23 00:00 [pmc-release] AID - pathogens10101227 [pii] AID - pathogens-10-01227 [pii] AID - 10.3390/pathogens10101227 [doi] PST - epublish SO - Pathogens. 2021 Sep 23;10(10):1227. doi: 10.3390/pathogens10101227.