PMID- 34684463 OWN - NLM STAT- MEDLINE DCOM- 20211129 LR - 20211129 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 13 IP - 10 DP - 2021 Sep 29 TI - Relationship between Dietary Fatty Acid Intake with Nonalcoholic Fatty Liver Disease and Liver Fibrosis in People with HIV. LID - 10.3390/nu13103462 [doi] LID - 3462 AB - We aimed to evaluate the relationship between food intake of lipids with nonalcoholic fatty liver disease (NAFLD) and/or liver fibrosis in people living with HIV/AIDS (PLWHA). In this cross-sectional study, transient elastography was used to detect the presence of NAFLD and/or liver fibrosis. The dietary intake of fats and fatty acids (FA) were assessed by two 24 h dietary recalls (24-HDR) (n = 451). Multivariate logistic regression models were performed. Participants with higher intake of total fat were associated with higher odds for NAFLD compared to those with lower consumption [adjusted odds ratio (aOR) = 1.91 (95% confidence interval (95% CI) 1.06-3.44)]. Furthermore, participants with intermediate intake of n6-PUFA (n6-poly-unsaturated FA) and lauric FA had lower odds for NAFLD, respectively aOR = 0.54 (95% CI 0.3-0.98) and aOR = 0.42 (95% CI 0.22-0.78). Additionally, a higher intake of myristoleic FA (fourth quartile) was a significant protective factor for NAFLD [aOR = 0.56 (95% CI 0.32-0.99)]. Participants with higher intake of lauric FA [0.38 (95% CI 0.18-0.80)], myristic FA [0.38 (0.17-0.89)], palmitoleic FA [0.40 (0.19-0.82)] and oleic FA [0.35 (0.16-0.79)] had positively less odds of having liver fibrosis. On the other hand, higher intake of n-6 PUFA was significantly associated with fibrosis [aOR = 2.45 (95% CI 1.12-5.32)]. Dietary assessment of total fat and FA should be incorporated into HIV care as a tool for preventing NAFLD and fibrosis in PLWHA. FAU - de Almeida, Cristiane Fonseca AU - de Almeida CF AD - Grupo de Pesquisa Clinica em Nutricao e Doencas Infecciosas (GPClin_Nut), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. AD - Servico de Nutricao (SENUT), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - da Silva, Paula Simplicio AU - da Silva PS AUID- ORCID: 0000-0002-7414-9698 AD - Grupo de Pesquisa Clinica em Nutricao e Doencas Infecciosas (GPClin_Nut), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. AD - Servico de Nutricao (SENUT), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Cardoso, Claudia Santos de Aguiar AU - Cardoso CSA AD - Grupo de Pesquisa Clinica em Nutricao e Doencas Infecciosas (GPClin_Nut), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. AD - Servico de Nutricao (SENUT), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Moreira, Nathalia Gorni AU - Moreira NG AD - Servico de Nutricao (SENUT), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Antunes, Julliana Cormack AU - Antunes JC AD - Grupo de Pesquisa Clinica em Nutricao e Doencas Infecciosas (GPClin_Nut), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. AD - Servico de Nutricao (SENUT), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - de Andrade, Michelle Morata AU - de Andrade MM AD - Plataforma de Pesquisa Clinica, Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Silva, Julio AU - Silva J AD - Plataforma de Pesquisa Clinica, Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Araujo, Marina Campos AU - Araujo MC AUID- ORCID: 0000-0002-7980-6618 AD - Escola Nacional de Saude Publica-Fundacao Oswaldo Cruz (FIOCRUZ), 21031-210 Rio de Janeiro, Brazil. FAU - Peres, Wilza Arantes Ferreira AU - Peres WAF AUID- ORCID: 0000-0003-0269-5363 AD - Instituto de Nutricao Josue de Castro, Universidade Federal do Rio de Janeiro (UFRJ), 21941-902 Rio de Janeiro, Brazil. FAU - do Brasil, Pedro Emmanuel Alvarenga Americano AU - do Brasil PEAA AD - Grupo de Pesquisa Clinica em Nutricao e Doencas Infecciosas (GPClin_Nut), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. AD - Laboratorio de Pesquisa em Imunizacao e Vigilancia em Saude, Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Moreira, Ronaldo Ismerio AU - Moreira RI AUID- ORCID: 0000-0003-2680-4317 AD - Laboratorio de Pesquisa Clinica em DST/AIDS (LAPCLIN-AIDS), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Cardoso, Sandra W AU - Cardoso SW AD - Laboratorio de Pesquisa Clinica em DST/AIDS (LAPCLIN-AIDS), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Veloso, Valdilea G AU - Veloso VG AD - Laboratorio de Pesquisa Clinica em DST/AIDS (LAPCLIN-AIDS), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Grinsztejn, Beatriz AU - Grinsztejn B AD - Laboratorio de Pesquisa Clinica em DST/AIDS (LAPCLIN-AIDS), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - de Brito, Patricia Dias AU - de Brito PD AUID- ORCID: 0000-0002-3670-6692 AD - Grupo de Pesquisa Clinica em Nutricao e Doencas Infecciosas (GPClin_Nut), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. AD - Servico de Nutricao (SENUT), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. FAU - Perazzo, Hugo AU - Perazzo H AUID- ORCID: 0000-0003-0931-6418 AD - Laboratorio de Pesquisa Clinica em DST/AIDS (LAPCLIN-AIDS), Instituto Nacional de Infectologia Evandro Chagas-Fundacao Oswaldo Cruz (FIOCRUZ), 21040-360 Rio de Janeiro, Brazil. LA - eng GR - E-26/110.268/2014/Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro/ GR - 405.211/2016-3, 407.410/2013-9 and 301.520/2014-3/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ PT - Journal Article DEP - 20210929 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (Dietary Fats) RN - 0 (Fatty Acids) SB - IM MH - Adult MH - Biomarkers MH - Cross-Sectional Studies MH - Dietary Fats/administration & dosage/*metabolism MH - Disease Susceptibility MH - Elasticity Imaging Techniques MH - Fatty Acids/administration & dosage/*metabolism MH - Female MH - HIV Infections/*complications/epidemiology MH - Humans MH - Liver Cirrhosis/diagnosis/epidemiology/*etiology/*metabolism MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Non-alcoholic Fatty Liver Disease/diagnosis/epidemiology/*etiology/*metabolism MH - Risk Assessment MH - Risk Factors PMC - PMC8539489 OTO - NOTNLM OT - HIV infection OT - NAFLD OT - dietary fats OT - liver fibrosis COIS- The authors declare no conflict of interest. EDAT- 2021/10/24 06:00 MHDA- 2021/11/30 06:00 PMCR- 2021/09/29 CRDT- 2021/10/23 01:18 PHST- 2021/07/06 00:00 [received] PHST- 2021/09/20 00:00 [revised] PHST- 2021/09/20 00:00 [accepted] PHST- 2021/10/23 01:18 [entrez] PHST- 2021/10/24 06:00 [pubmed] PHST- 2021/11/30 06:00 [medline] PHST- 2021/09/29 00:00 [pmc-release] AID - nu13103462 [pii] AID - nutrients-13-03462 [pii] AID - 10.3390/nu13103462 [doi] PST - epublish SO - Nutrients. 2021 Sep 29;13(10):3462. doi: 10.3390/nu13103462.