PMID- 34684648
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20221207
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 10
DP  - 2021 Oct 18
TI  - Association of Obesity with the Risk of Hyperhomocysteinemia among the Chinese 
      Community Residents: A Prospective Cohort Study in Shanghai, China.
LID - 10.3390/nu13103648 [doi]
LID - 3648
AB  - A prospective community-based cohort study was conducted to investigate the 
      effects of obesity on hyperhomocysteinemia (HHcy) in community residents from 
      Shanghai, China, with a median follow-up period of 2.98 years. The exposures were 
      high body mass index (BMI) (BMI >/= 28.0 kg/m(2)) and high waist circumference (WC) 
      (WC >/= 85.0 cm for female and WC >/= 90.0 for male) at baseline investigation, and 
      the outcome was the incident of HHcy after the follow-up. A restricted cubic 
      spline (RCS) was performed to assess the possible nonlinear relationship of BMI 
      and WC with HHcy. A Cox proportional hazard regression model was used to evaluate 
      the association between BMI and WC measured obesity and the risk of HHcy (Hcy 
      level > 15 micromol/L). No significant non-linearity was found between BMI and WC 
      with HHcy. Cox regression model showed that underweight measured by BMI was 
      negatively associated with the risk of HHcy after controlling for confounder 
      variables (adjusted HR = 0.64, 95% CI = 0.42 to 0.99). While abdominal obesity 
      was positively associated with the risk of HHcy for those without CVD-related 
      comorbidities (adjusted HR = 1.26, 95% CI = 1.05 to 1.51). Our results suggested 
      that individuals could maintain a relatively low BMI and normal WC to lower the 
      risk of HHcy.
FAU - Xiang, Yu
AU  - Xiang Y
AUID- ORCID: 0000-0001-7874-9298
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, 
      China.
FAU - Zhao, Qi
AU  - Zhao Q
AUID- ORCID: 0000-0003-0140-3920
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, 
      China.
FAU - Wang, Na
AU  - Wang N
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, 
      China.
FAU - Yu, Yuting
AU  - Yu Y
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, 
      China.
FAU - Wang, Ruiping
AU  - Wang R
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Zhang, Yue
AU  - Zhang Y
AD  - Department of Epidemiology, School of Public Health, Shanxi Medical University, 
      Taiyuan 030001, China.
FAU - Cui, Shuheng
AU  - Cui S
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, 
      China.
FAU - Wu, Yiling
AU  - Wu Y
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Liu, Xing
AU  - Liu X
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, 
      China.
FAU - Jiang, Yonggen
AU  - Jiang Y
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201600, 
      China.
FAU - Yu, Yongfu
AU  - Yu Y
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Biostatistics, School of Public Health, Fudan University, Shanghai 200032, 
      China.
FAU - Zhao, Genming
AU  - Zhao G
AD  - The Key Laboratory of Public Health Safety of Ministry of Education, Department 
      of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, 
      China.
LA  - eng
GR  - 2017YFC0907000/National Key Research and Development Program of China/
GR  - GWV-10.1-XK16/Shanghai New Three-year Action Plan for Public Health/
PT  - Journal Article
DEP - 20211018
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Asian People
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Confidence Intervals
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Male
MH  - Middle Aged
MH  - Nonlinear Dynamics
MH  - Obesity/*complications
MH  - *Residence Characteristics
MH  - Waist Circumference
MH  - Young Adult
PMC - PMC8537264
OTO - NOTNLM
OT  - Chinese community residents
OT  - cohort study
OT  - hyperhomocysteinemia
OT  - obesity
COIS- The authors declared no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/11/20 06:00
PMCR- 2021/10/18
CRDT- 2021/10/23 01:19
PHST- 2021/09/12 00:00 [received]
PHST- 2021/10/09 00:00 [revised]
PHST- 2021/10/15 00:00 [accepted]
PHST- 2021/10/23 01:19 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2021/10/18 00:00 [pmc-release]
AID - nu13103648 [pii]
AID - nutrients-13-03648 [pii]
AID - 10.3390/nu13103648 [doi]
PST - epublish
SO  - Nutrients. 2021 Oct 18;13(10):3648. doi: 10.3390/nu13103648.