PMID- 34685444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211026
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Oct 11
TI  - Uncovering the Roles of MicroRNAs in Major Depressive Disorder: From Candidate 
      Diagnostic Biomarkers to Treatment Response Indicators.
LID - 10.3390/life11101073 [doi]
LID - 1073
AB  - Major depressive disorder (MDD) is a recurrent debilitating illness that 
      represents a major health burden due to its increasing worldwide prevalence, 
      unclear pathological mechanism, nonresponsive treatment, and lack of reliable and 
      specific diagnostic biomarkers. Recently, microRNA species (miRs) have gained 
      particular interest because they have the ability to post-transcriptionally 
      regulate gene expression by modulating mRNA stability and translation in a 
      cohesive fashion. By regulating entire genetic circuitries, miRs have been shown 
      to have dysregulated expression levels in blood samples from MDD patients, when 
      compared to healthy subjects. In addition, antidepressant treatment (AD) also 
      appears to alter the expression pattern of several miRs. Therefore, we critically 
      and systematically reviewed herein the studies assessing the potential biomarker 
      role of several candidate miRs for MDD, as well as treatment response monitoring 
      indicators, in order to enrich the current knowledge and facilitate possible 
      diagnostic biomarker development for MDD, which could aid in reducing both 
      patients' burden and open novel avenues toward a better understanding of MDD 
      neurobiology.
FAU - Homorogan, Claudia
AU  - Homorogan C
AUID- ORCID: 0000-0002-0256-2117
AD  - Department of Biochemistry, University of Medicine and Pharmacy Victor Babes 
      Timisoara, 300041 Timisoara, Romania.
FAU - Nitusca, Diana
AU  - Nitusca D
AUID- ORCID: 0000-0002-5325-5221
AD  - Department of Biochemistry, University of Medicine and Pharmacy Victor Babes 
      Timisoara, 300041 Timisoara, Romania.
FAU - Seclaman, Edward
AU  - Seclaman E
AD  - Department of Biochemistry, University of Medicine and Pharmacy Victor Babes 
      Timisoara, 300041 Timisoara, Romania.
FAU - Enatescu, Virgil
AU  - Enatescu V
AD  - Discipline of Psychiatry, Department of Neurosciences, University of Medicine and 
      Pharmacy Victor Babes Timisoara, 300041 Timisoara, Romania.
AD  - Eduard Pamfil Psychiatric Clinic, Timisoara County Emergency Clinical Hospital, 
      300041 Timisoara, Romania.
FAU - Marian, Catalin
AU  - Marian C
AUID- ORCID: 0000-0002-7749-1384
AD  - Department of Biochemistry, University of Medicine and Pharmacy Victor Babes 
      Timisoara, 300041 Timisoara, Romania.
LA  - eng
GR  - 4EXP/1232/2020/Victor Babes University of Medicine and Pharmacy Timisoara/
PT  - Journal Article
PT  - Review
DEP - 20211011
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC8538902
OTO - NOTNLM
OT  - antidepressant treatment
OT  - biomarkers
OT  - major depressive disorder
OT  - microRNAs
COIS- The authors declare no conflict of interest.
EDAT- 2021/10/24 06:00
MHDA- 2021/10/24 06:01
PMCR- 2021/10/11
CRDT- 2021/10/23 01:22
PHST- 2021/09/16 00:00 [received]
PHST- 2021/10/06 00:00 [revised]
PHST- 2021/10/08 00:00 [accepted]
PHST- 2021/10/23 01:22 [entrez]
PHST- 2021/10/24 06:00 [pubmed]
PHST- 2021/10/24 06:01 [medline]
PHST- 2021/10/11 00:00 [pmc-release]
AID - life11101073 [pii]
AID - life-11-01073 [pii]
AID - 10.3390/life11101073 [doi]
PST - epublish
SO  - Life (Basel). 2021 Oct 11;11(10):1073. doi: 10.3390/life11101073.